Transcriptome-wide analysis of exosome targets
The exosome plays major roles in RNA processing and surveillance but the in vivo target
range and substrate acquisition mechanisms remain unclear. Here we apply in vivo RNA …
range and substrate acquisition mechanisms remain unclear. Here we apply in vivo RNA …
Transcriptome-wide analysis of alternative routes for RNA substrates into the exosome complex
C Delan-Forino, C Schneider, D Tollervey - PLoS genetics, 2017 - journals.plos.org
The RNA exosome complex functions in both the accurate processing and rapid
degradation of many classes of RNA. Functional and structural analyses indicate that RNA …
degradation of many classes of RNA. Functional and structural analyses indicate that RNA …
Threading the barrel of the RNA exosome
C Schneider, D Tollervey - Trends in biochemical sciences, 2013 - cell.com
In eukaryotes, the exosome complex degrades RNA backbones and plays key roles in RNA
processing and surveillance. It was predicted that RNA substrates are threaded through a …
processing and surveillance. It was predicted that RNA substrates are threaded through a …
Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits
DL Kiss, ED Andrulis - Rna, 2010 - rnajournal.cshlp.org
The RNA processing exosome complex was originally defined as an evolutionarily
conserved multisubunit complex of ribonucleases responsible for the processing and/or …
conserved multisubunit complex of ribonucleases responsible for the processing and/or …
Extensive degradation of RNA precursors by the exosome in wild-type cells
RK Gudipati, Z Xu, A Lebreton, B Séraphin… - Molecular cell, 2012 - cell.com
The exosome is a complex involved in the maturation of rRNA and sn-snoRNA, in the
degradation of short-lived noncoding RNAs, and in the quality control of RNAs produced in …
degradation of short-lived noncoding RNAs, and in the quality control of RNAs produced in …
[HTML][HTML] The yeast exosome functions as a macromolecular cage to channel RNA substrates for degradation
F Bonneau, J Basquin, J Ebert, E Lorentzen, E Conti - Cell, 2009 - cell.com
The exosome is a conserved macromolecular complex essential for RNA degradation. The
nine-subunit core of the eukaryotic exosome shares a similar barrel-like architecture with …
nine-subunit core of the eukaryotic exosome shares a similar barrel-like architecture with …
The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome
EV Wasmuth, CD Lima - Nucleic acids research, 2017 - academic.oup.com
The eukaryotic RNA exosome is an essential, multi-subunit complex that catalyzes RNA
turnover, maturation, and quality control processes. Its non-catalytic donut-shaped core …
turnover, maturation, and quality control processes. Its non-catalytic donut-shaped core …
The human nuclear exosome targeting complex is loaded onto newly synthesized RNA to direct early ribonucleolysis
M Lubas, PR Andersen, A Schein, A Dziembowski… - Cell reports, 2015 - cell.com
The RNA exosome complex constitutes the major nuclear eukaryotic 3′-5′ exonuclease.
Outside of nucleoli, the human nucleoplasmic exosome is directed to some of its substrates …
Outside of nucleoli, the human nucleoplasmic exosome is directed to some of its substrates …
The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing
Y Chen, Y Li, RS Dai, JC Savage, U Shinde… - Nucleic acids …, 2023 - academic.oup.com
The RNA exosome is an essential 3′ to 5′ exoribonuclease complex that mediates
degradation, processing and quality control of virtually all eukaryotic RNAs. The nucleolar …
degradation, processing and quality control of virtually all eukaryotic RNAs. The nucleolar …
Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors
The eukaryotic RNA exosome is an essential and conserved protein complex that can
degrade or process RNA substrates in the 3′-to-5′ direction. Since its discovery nearly …
degrade or process RNA substrates in the 3′-to-5′ direction. Since its discovery nearly …