The exosome is a complex of 3′–5′ exoribonucleases and RNA-binding proteins, which
is involved in processing or degradation of different classes of RNA. Previously, the …

Defective RNAs and proteins are swiftly degraded by cellular quality control mechanisms. A
large fraction of their degradation is mediated by the exosome and the proteasome. These …

The exosome is a multi-subunit protein complex involved in essentially all phenomena
associated with RNA metabolism in eukaryotic cells. This review discusses recent …

The RNA-processing exosome is a complex of riboexonucleases required for 3′-end
formation of some noncoding RNAs and for the degradation of mRNAs in eukaryotes. The …

Related exosome complexes of 3′→ 5′ exonucleases are present in the nucleus and the
cytoplasm. Purification of exosome complexes from whole-cell lysates identified a Mg 2+ …

The exosome, an evolutionarily conserved complex of multiple 3′→ 5′ exoribonucleases,
is responsible for a variety of RNA processing and degradation events in eukaryotes. In this …

Eukaryotic 3′→ 5′ exonucleolytic activities are essential for a wide variety of reactions of
RNA maturation and metabolism, including processing of rRNA, small nuclear RNA, and …

The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism.
Here we show that the exosome is necessary for the repair of DNA double-strand breaks …

The eukaryotic exosome is a macromolecular complex essential for RNA processing and
decay. It has recently been shown that the RNase activity of the yeast exosome core can be …

Recent data reveal that a substantial fraction of transcripts generated by RNA polymerases I,
II, and III are rapidly degraded in the nucleus by the combined action of the exosome and a …