Persistent Plasmodium falciparum infections enhance transmission-reducing immunity development

R Ayanful-Torgby, E Sarpong, HB Abagna, D Donu… - Scientific Reports, 2021 - nature.com
Subclinical infections that serve as reservoir populations to drive transmission remain a
hurdle to malaria control. Data on infection dynamics in a geographical area is required to …

Immune Responses to Gametocyte Antigens in a Malaria Endemic Population—The African falciparum Context: A Systematic Review and Meta-Analysis

K Muthui Michelle, K Alice, B Teun… - Frontiers in …, 2020 - frontiersin.org
< p>< bold> Background: Malaria elimination remains a priority research agenda with the
need for interventions that reduce and/or block malaria transmission from humans to …

Immune Responses to Gametocyte Antigens in a Malaria Endemic Population—The African falciparum Context: A Systematic Review and Meta-Analysis

MK Muthui, A Kamau, T Bousema… - Frontiers in …, 2019 - frontiersin.org
Background: Malaria elimination remains a priority research agenda with the need for
interventions that reduce and/or block malaria transmission from humans to mosquitoes …

Dynamics of anti-MSP3 and Pfs230 antibody responses and multiplicity of infection in asymptomatic children from southern Ghana

LE Amoah, FK Acquah, R Ayanful-Torgby, A Oppong… - Parasites & vectors, 2018 - Springer
Abstract Background During a Plasmodium infection, exposure of human host immune cells
to both the asexual and the sexual stages of the parasite elicit immune responses. These …

The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections

RM de Jong, M Alkema, T Oulton, E Dumont… - Frontiers in …, 2022 - frontiersin.org
Individuals infected with P. falciparum develop antibody responses to intra-erythrocytic
gametocyte proteins and exported gametocyte proteins present on the surface of infected …

Plasmodium falciparum gametocyte-specific antibody profiling reveals boosting through natural infection and identifies potential markers of gametocyte exposure

J Skinner, CY Huang, M Waisberg… - Infection and …, 2015 - Am Soc Microbiol
Malaria elimination efforts would benefit from vaccines that block transmission of
Plasmodium falciparum gametocytes from humans to mosquitoes. A clear understanding of …

Diversity and immune responses against Plasmodium falciparum gametocytes in non-febrile school children living in Southern Ghana

LE Amoah, HB Abagna, R Ayanful-Torgby… - Malaria Journal, 2019 - Springer
Background Natural exposure to gametocytes can result in the development of immunity
against the gametocyte by the host as well as genetic diversity in the gametocyte. This study …

[HTML][HTML] Characterization of Naturally Acquired Immunity to a Panel of Antigens Expressed in Mature P. falciparum Gametocytes

MK Muthui, E Takashima, BR Omondi… - Frontiers in cellular …, 2021 - frontiersin.org
Introduction Naturally acquired immune responses against antigens expressed on the
surface of mature gametocytes develop in individuals living in malaria-endemic areas …

Breadth of Functional Antibodies Is Associated With Plasmodium falciparum Merozoite Phagocytosis and Protection Against Febrile Malaria

IH Kana, SK Singh, A Garcia-Senosiain… - The Journal of …, 2019 - academic.oup.com
Background The specific targets of functional antibodies against Plasmodium falciparum
merozoites remain largely unexplored and, more importantly, their relevance to naturally …

Microscopic and submicroscopic asymptomatic Plasmodium falciparum infections in Ghanaian children and protection against febrile malaria

B Adu, Q Issahaque, T Sarkodie-Addo… - Infection and …, 2020 - Am Soc Microbiol
Naturally acquired immunity to Plasmodium falciparum malaria is thought to be nonsterile
and sustained by persistence of low-level parasitemia. This study assessed the association …