Traumatic brain injury (TBI) causes microglial activation and related neurotoxicity that
contributes to chronic neurodegeneration and loss of neurological function. Selective …

Traumatic brain injury causes progressive neurodegeneration associated with chronic
microglial activation. Recent studies show that neurodegeneration and neuroinflammation …

We have previously shown that treatment with a mGluR5 positive allosteric modulator (PAM)
is neuroprotective after experimental traumatic brain injury (TBI), limiting post‐traumatic …

Several previous studies utilizing selective pharmacological antagonists have demonstrated
that type 5 metabotropic glutamate receptors (mGluR5) are potential therapeutic targets for …

Background Traumatic brain injury initiates biochemical processes that lead to secondary
neurodegeneration. Imaging studies suggest that tissue loss may continue for months or …

Traumatic brain injury (TBI) induces microglial activation, which can contribute to secondary
tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial …

Group I metabotropic glutamate receptors (mGluRs) have been implicated in the
pathophysiology of central nervous system injury, but the role of mGluR5 in traumatic brain …

The effects of group II mGluR activation by selective agonist (–)-2-oxa-4-aminobicyclo [3.1.
0] hexane-4, 6-dicarboxylate (LY379268) were examined in a mouse model of controlled …

The effects of selective blockade of group I metabotropic glutamate receptor subtype 1
(mGluR1) on neuronal cell survival and post-traumatic recovery was examined using rat in …

The role of phospholipase C-coupled (group I) metabotropic glutamate receptors (mGluR1
and mGluR5) in post-traumatic neuronal injury was examined using rat in vivo and in vitro …