Novel mGluR5 positive allosteric modulator improves functional recovery, attenuates neurodegeneration, and alters microglial polarization after experimental …
Traumatic brain injury (TBI) causes microglial activation and related neurotoxicity that
contributes to chronic neurodegeneration and loss of neurological function. Selective …
contributes to chronic neurodegeneration and loss of neurological function. Selective …
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGluR5) attenuate microglial activation
F Xue, BA Stoica, M Hanscom… - CNS & Neurological …, 2014 - ingentaconnect.com
Traumatic brain injury causes progressive neurodegeneration associated with chronic
microglial activation. Recent studies show that neurodegeneration and neuroinflammation …
microglial activation. Recent studies show that neurodegeneration and neuroinflammation …
Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain …
SA Bhat, RJ Henry, AC Blanchard… - Journal of …, 2021 - Wiley Online Library
We have previously shown that treatment with a mGluR5 positive allosteric modulator (PAM)
is neuroprotective after experimental traumatic brain injury (TBI), limiting post‐traumatic …
is neuroprotective after experimental traumatic brain injury (TBI), limiting post‐traumatic …
Protective effects of mGluR5 positive modulators against traumatic neuronal injury through PKC-dependent activation of MEK/ERK pathway
T Chen, L Cao, WP Dong, P Luo, WB Liu, Y Qu… - Neurochemical …, 2012 - Springer
Several previous studies utilizing selective pharmacological antagonists have demonstrated
that type 5 metabotropic glutamate receptors (mGluR5) are potential therapeutic targets for …
that type 5 metabotropic glutamate receptors (mGluR5) are potential therapeutic targets for …
Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury
Background Traumatic brain injury initiates biochemical processes that lead to secondary
neurodegeneration. Imaging studies suggest that tissue loss may continue for months or …
neurodegeneration. Imaging studies suggest that tissue loss may continue for months or …
Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury
Traumatic brain injury (TBI) induces microglial activation, which can contribute to secondary
tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial …
tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial …
[HTML][HTML] The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway
T Chen, L Zhang, Y Qu, K Huo… - … journal of molecular …, 2012 - spandidos-publications.com
Group I metabotropic glutamate receptors (mGluRs) have been implicated in the
pathophysiology of central nervous system injury, but the role of mGluR5 in traumatic brain …
pathophysiology of central nervous system injury, but the role of mGluR5 in traumatic brain …
Neuroprotective effects of selective group II mGluR activation in brain trauma and traumatic neuronal injury
VA Movsesyan, AI Faden - Journal of neurotrauma, 2006 - liebertpub.com
The effects of group II mGluR activation by selective agonist (–)-2-oxa-4-aminobicyclo [3.1.
0] hexane-4, 6-dicarboxylate (LY379268) were examined in a mouse model of controlled …
0] hexane-4, 6-dicarboxylate (LY379268) were examined in a mouse model of controlled …
Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improves outcome after brain trauma
AI Faden, DM O'Leary, L Fan, W Bao, PGM Mullins… - Experimental …, 2001 - Elsevier
The effects of selective blockade of group I metabotropic glutamate receptor subtype 1
(mGluR1) on neuronal cell survival and post-traumatic recovery was examined using rat in …
(mGluR1) on neuronal cell survival and post-traumatic recovery was examined using rat in …
Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury
A Mukhin, L Fan, AI Faden - Journal of Neuroscience, 1996 - Soc Neuroscience
The role of phospholipase C-coupled (group I) metabotropic glutamate receptors (mGluR1
and mGluR5) in post-traumatic neuronal injury was examined using rat in vivo and in vitro …
and mGluR5) in post-traumatic neuronal injury was examined using rat in vivo and in vitro …
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