The gut microbiome is shaped by diet and influences host metabolism; however, these links
are complex and can be unique to each individual. We performed deep metagenomic …

For decades, dietary advice was based on the premise that high intakes of fat cause obesity,
diabetes, heart disease, and possibly cancer. Recently, evidence for the adverse metabolic …

Metabolic diseases represent a growing threat to world-wide public health. In general, these
disorders result from the interaction of heritable factors with environmental influences. Here …

The serum metabolome contains a plethora of biomarkers and causative agents of various
diseases, some of which are endogenously produced and some that have been taken up …

Until recently, nutrition research concentrated on nutrient deficiencies and impairment of
health. The advent of genomics—interpreted broadly as a suite of high throughput …

The epidemic of obesity-associated diabetes is a major crisis in modern societies, in which
food is plentiful and exercise is optional. The biological basis of this problem has been …

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved
insight into disease etiology. We analyzed 386,731 common single-nucleotide …

Elevated postprandial blood glucose levels constitute a global epidemic and a major risk
factor for prediabetes and type II diabetes, but existing dietary methods for controlling them …

The pandemic of diabetes poses an enormous public health challenge for almost every
country across the globe. 1, 2 In 2014, more than 380 million people were living with …

Obesity and type 2 diabetes are causally related, yet there is considerable heterogeneity in
the consequences of both conditions and the mechanisms of action are poorly defined. Here …