Cyanate induces oxidative stress injury and abnormal lipid metabolism in liver through Nrf2/HO-1

L Hu, K Tian, T Zhang, CH Fan, P Zhou, D Zeng… - Molecules, 2019 - mdpi.com
Chronic kidney disease (CKD) is problem that has become one of the major issues affecting
public health. Extensive clinical data suggests that the prevalence of hyperlipidemia in CKD …

Simvastatin activates Keap1/Nrf2 signaling in rat liver

IG Habeos, PG Ziros, D Chartoumpekis… - Journal of Molecular …, 2008 - Springer
Some of the statins' pleiotropic actions have been attributed to their antioxidant activity. The
Nrf2 transcription factor controls the expression of a number of protective genes in response …

Cyanidin Alleviated CCl4-Induced Acute Liver Injury by Regulating the Nrf2 and NF-κB Signaling Pathways

B Wang, S Cui, B Mao, Q Zhang, F Tian, J Zhao… - Antioxidants, 2022 - mdpi.com
Acute liver injury has multiple causes and can result in liver failure. In this study, we
evaluated the hepatoprotective ability of cyanidin (Cy) and investigated its associated …

The protective effect of hyperoside on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2

L Zou, S Chen, L Li, T Wu - Experimental and Toxicologic Pathology, 2017 - Elsevier
Context Hyperoside was used to treat cardiovascular disease for many years in China. It
was shown great effect on regulation of lipid metabolism. But there is lack of reports about …

Dibenzoylmethane protects against CCl4-induced acute liver injury by activating Nrf2 via JNK, AMPK, and calcium signaling

M Cao, H Wang, L Guo, S Yang, C Liu, TO Khor, S Yu… - The AAPS Journal, 2017 - Springer
Oxidative stress is an important pathogenic factor in various hepatic diseases. Nuclear factor-
erythroid 2-related factor-2 (Nrf2), which coordinates the expression of an array of …

Synergistic effect of cyanidin and PPAR agonist against nonalcoholic steatohepatitis-mediated oxidative stress-induced cytotoxicity through MAPK and Nrf2 …

PH Shih, SL Hwang, CT Yeh… - Journal of agricultural and …, 2012 - ACS Publications
Nonalcoholic steatohepatitis (NASH) is caused by an elevation in oxidative stress, which
might further lead to hepatic fibrogenesis. Importantly, both peroxisome proliferator-activated …

MCFA alleviate H2O2‐induced oxidative stress in AML12 cells via the ERK1/2/Nrf2 pathway

D Wang, J Chen, H Sun, W Chen, X Yang - Lipids, 2022 - Wiley Online Library
Oxidative stress is an important factor in the occurrence and development of liver disease.
Medium‐chain fatty acids (MCFAs) have potential antioxidant function, whereas the exact …

[HTML][HTML] Cyanidin-3-glucoside protects liver from oxidative damage through AMPK/Nrf2 mediated signaling pathway in vivo and in vitro

L Yu, S Zhang, X Zhao, H Ni, X Song, W Wang… - Journal of Functional …, 2020 - Elsevier
Abstract Cyanidin-3-glucoside (C3G) has been demonstrated to have hepatoprotective
effect for oxidative stress-related liver damage due to its antioxidant activity. However, the …

Erythritol improves nonalcoholic fatty liver disease by activating Nrf2 antioxidant capacity

M Jin, Y Wei, H Yu, X Ma, S Yan, L Zhao… - Journal of Agricultural …, 2021 - ACS Publications
Nonalcoholic fatty liver disease (NAFLD) is a kind of serious fat disorder that has become a
critical problem to human society. Therefore, finding drugs that are safe and effective has …

Safflower yellow B suppresses HepG2 cell injury induced by oxidative stress through the AKT/Nrf2 pathway

Z Ma, C Li, Y Qiao, C Lu, J Li… - International …, 2016 - spandidos-publications.com
Oxidative stress plays an important role in the pathogenesis of various liver diseases.
Safflower yellow B (SYB) has been reported to protect the brain against damage induced by …