Integrin activation is essential for dynamically linking the extracellular environment and
cytoskeletal/signaling networks. Activation is controlled by integrins' short cytoplasmic tails …

Integrin activation, the rapid conversion of integrin adhesion receptors from low to high
affinity, occurs in response to intracellular signals that act on the short cytoplasmic tails of …

Integrin Bidirectional Signaling: A Molecular View | PLOS Biology Skip to main content
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Integrins are αβ heterodimeric adhesion receptors that relay signals bidirectionally across
the plasma membrane between the extracellular matrix and cell-surface ligands, and …

Integrins are transmembrane cell–adhesion molecules that carry signals from the outside to
the inside of the cell and vice versa. Like other cell surface receptors, integrins signal in …

Integrins play critical roles in development, wound healing, immunity and cancer. Central to
their function is their unique ability to modulate dynamically their adhesiveness through both …

While it is self-evident that all extracellular molecules are an integral part of a multicellular
organism, it is paradoxical that they are often considered to be dissociated from cells. The …

Integrins are large, membrane-spanning, heterodimeric proteins that are essential for a
metazoan existence. All members of the integrin family adopt a shape that resembles a large …

Complexity and specificity of integrin signalling | Nature Cell Biology Skip to main content
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Adhesive interactions play critical roles in directing the migration, proliferation, and
differentiation of cells; aberrations in such interactions can lead to pathological disorders …