2002). They are non-covalently associated heterodimers consisting of a-and bsubunits. On
the cell surface, integrins exist in a conformation with either high (active) or low (inactive) …

Integrins are an important family of adhesion molecules that were first discovered two
decades ago. Integrins are transmembrane heterodimeric glycoprotein receptors consisting …

Integrins are adhesion receptors that connect cells to components of the extracellular matrix
or to counter receptors on other cells. Besides mediating stable adhesion, these receptors …

Integrin‐mediated cell–ECM (extracellular matrix) adhesion is a fundamental process that
controls cell behaviour. For correct cell–ECM adhesion, both the ligand‐binding affinity and …

Integrins are adhesion molecules that convey signals both to and from the cytoplasm across
the plasma membrane. In resting cells, integrins in a low affinity state can be activated …

Integrins are the principal cell adhesion receptors that mediate leukocyte migration and
activation in the immune system. These receptors signal bidirectionally through the plasma …

The integrin family of extracellular matrix receptors regulates many aspects of cell life, in
particular cell adhesion and migration. These two processes depend on organization of the …

Integrins mediate cell–matrix and cell–cell interactions and integrate extracellular cues to
the cytoskeleton and cellular signalling pathways. Integrin function on the cell surface is …

Integrin adhesion receptors can signal in two directions: first, they can regulate cellular
behaviors by modulating cellular signaling enzymes (" outside-in signaling"); second, cells …

Background Integrin receptors, composed of transmembrane α and β subunits, are essential
for the development and functioning of multicellular animals. Agonist stimulation leads cells …