In this review, I have discussed various issues of the cancer drug targeting primarily related
to the EPR (enhanced permeability and retention) effect, which utilized nanomedicine or …

The exploitation of nanosized materials for the delivery of therapeutic agents is already a
clinical reality and still holds unrealized potential for the treatment of a variety of diseases …

Tumor and inflammation have many common features. One hallmark of both is enhanced
vascular permeability, which is mediated by various factors including bradykinin, nitric oxide …

The use of nanomedicine for cancer treatment takes advantage of its preferential
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …

Simple Summary One of the important efforts in the treatment of cancers is to achieve
targeted drug delivery by nanocarriers to be more effective and reduce adverse effects …

Effective tumor treatment depends on optimizing drug penetration and accumulation in
tumor tissue while minimizing systemic toxicity. Nanomedicine has emerged as a key …

Targeted drug delivery to tumor sites is one of the ultimate goals in drug delivery. Recent
progress in nanoparticle engineering has certainly improved drug targeting, but the results …

Classic chemotherapy has little or no specificity for cancer cells, normally resulting in low
accumulation at the tumor region (inefficacy), and in severe side effects (toxicity). This …

Chemotherapy for human solid tumors in clinical practice is far from satisfactory. Despite the
discovery and synthesis of hundreds of thousands of anticancer compounds targeting …

To efficiently deliver therapeutics into cancer cells, a number of strategies have been
recently investigated. The toxicity associated with the administration of chemotherapeutic …