Nanotherapeutics have improved the quality of life of cancer patients, primarily by reducing
the adverse effects of chemotherapeutic agents, but improvements in overall survival are …

Enhanced permeability and retention (EPR) effect–based nanomedicine is a promising
strategy for successful anticancer therapy. The EPR effect is based on tumor blood flow …

Recent advances in nanotechnology have offered new hope for cancer detection,
prevention, and treatment. While the enhanced permeability and retention effect has served …

Over the last decade, significant progress has been made in the field of drug delivery. The
advent of engineered nanoparticles has allowed us to circumvent the initial limitations to …

All intravenous delivered nanomedicine needs to escape from the blood vessel to exert their
therapeutic efficacy at their designated site of action. Failure to do so increases the …

The characteristics of the primary tumor blood vessels and the tumor microenvironment drive
the enhanced permeability and retention (EPR) effect, which confers an advantage towards …

Passive targeting of large nanoparticles by the enhanced permeability and retention (EPR)
effect is a crucial concept for solid tumor targeting in cancer nanomedicine. There is …

Tumor microvasculature is fraught with numerous physiological barriers which hinder the
efficacy of anticancer agents. These barriers include chaotic blood supply, poor tumor …

Pancreatic cancer (PCa) is one of the leading causes of morbidity worldwide, and
theranostic approaches are ventured. The vast stroma surrounding PCa cells has been …

Nanoparticle drug delivery to the tumor is impacted by multiple factors: nanoparticles must
evade clearance by renal filtration and the reticuloendothelial system, extravasate through …