Evolution and functional cross‐talk of protein post‐translational modifications

P Beltrao, P Bork, NJ Krogan… - Molecular systems …, 2013 - embopress.org
Protein post‐translational modifications (PTM s) allow the cell to regulate protein activity and
play a crucial role in the response to changes in external conditions or internal states …

The evolution of post-translational modifications

D Bradley - Current Opinion in Genetics & Development, 2022 - Elsevier
Post-translational modifications (PTMs) are chemical modifications that can regulate the
activity and function of proteins. From an evolutionary perspective, they also represent a fast …

The next level of complexity: crosstalk of posttranslational modifications

AS Venne, L Kollipara, RP Zahedi - Proteomics, 2014 - Wiley Online Library
Beside gene expression and translational control, which are relatively slow, PTM of proteins
represents the major level of regulation, from very fast and reversible to slow or irreversible …

Mass spectrometry-based detection and assignment of protein posttranslational modifications

S Doll, AL Burlingame - ACS chemical biology, 2015 - ACS Publications
Recent advances in mass spectrometry (MS)-based proteomics allow the identification and
quantitation of thousands of posttranslational modification (PTM) sites in a single …

dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications

Z Li, S Li, M Luo, JH Jhong, W Li, L Yao… - Nucleic acids …, 2022 - academic.oup.com
Protein post-translational modifications (PTMs) play an important role in different cellular
processes. In view of the importance of PTMs in cellular functions and the massive data …

Analysis and interpretation of protein post-translational modification site stoichiometry

G Prus, A Hoegl, BT Weinert, C Choudhary - Trends in biochemical …, 2019 - cell.com
Proteins are decorated with a diverse array of post-translational modifications (PTMs) that
regulate their spatial and temporal functions. Recent mass spectrometry (MS)-based studies …

Identification and quantification of protein posttranslational modifications

AR Farley, AJ Link - Methods in enzymology, 2009 - Elsevier
Posttranslational modifications (PTMs) of proteins perform crucial roles in regulating the
biology of the cell. PTMs are enzymatic, covalent chemical modifications of proteins that …

A global view of the human post-translational modification landscape

N Kitamura, JJ Galligan - Biochemical Journal, 2023 - portlandpress.com
Post-translational modifications (PTMs) provide a rapid response to stimuli, finely tuning
metabolism and gene expression and maintain homeostasis. Advances in mass …

Decoding post-translational modification crosstalk with proteomics

M Leutert, SW Entwisle, J Villén - Molecular & Cellular Proteomics, 2021 - ASBMB
Post-translational modification (PTM) of proteins allows cells to regulate protein functions,
transduce signals and respond to perturbations. PTMs expand protein functionality and …

Deciphering a global network of functionally associated post‐translational modifications

P Minguez, L Parca, F Diella, DR Mende… - Molecular systems …, 2012 - embopress.org
Various post‐translational modifications (PTMs) fine‐tune the functions of almost all
eukaryotic proteins, and co‐regulation of different types of PTMs has been shown within and …