A major obstacle in Alzheimer's disease (AD) research is the lack of predictive and
translatable animal models that reflect disease progression and drug efficacy. Transgenic …

Animal models of human diseases that accurately recapitulate clinical pathology are
indispensable for understanding molecular mechanisms and advancing preclinical studies …

Transgenic (Tg) mice that overexpress mutant familial Alzheimer's disease (AD) amyloid
precursor protein (APP) genes have contributed to an understanding of dementia pathology …

Background Alzheimer's disease (AD) is a devastating neurodegenerative disorder that
affects a large and growing number of elderly individuals. In addition to idiopathic disease …

Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder. It
is widely accepted that AD is mainly caused by the accumulation of extracellular amyloid β …

In the last decade, multiple lines of transgenic APP overexpressing mice have been created
that recapitulate certain aspects of Alzheimer's disease (AD). However, none of the …

Since their initial generation in the mid 1990s, transgenic mouse models of Alzheimers′ s
disease (AD) have been proven to be valuable model systems which are indispensable for …

Transgenic mice expressing mutant human amyloid precursor protein (APP) develop an age-
dependent amyloid pathology and memory deficits, but no overt neuronal loss. Here, in mice …

The amyloid precursor protein (APP) has been under intensive study in recent years, mainly
due to its critical role in the pathogenesis of Alzheimer's disease (AD). β-Amyloid (Aβ) …

Altered concentrations of amyloid-β (Aβ) peptide and Tau protein in the cerebrospinal fluid
(CSF) are thought to be predictive markers for Alzheimer's disease (AD). Transgenic mice …