Time-of-flight secondary ion mass spectrometry (TOF-SIMS) can be utilized to map the
distribution of various molecules on a surface with submicrometer resolution. Much of its …

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is a well-established
bioanalytical method for directly imaging the chemical distribution across single cells. Here …

Time-Of-Flight Secondary Ion Mass Spectrometry is compared to other mass spectrometry
imaging techniques, and recent improvements of the experimental methods, driven by …

Fundamental advances in secondary ion mass spectrometry (SIMS) now allow for the
examination and characterization of lipids directly from biological materials. The successful …

Secondary ion mass spectrometry (SIMS) has been in use in biomedical imaging for more
than three decades and has resulted in some important biomedical discoveries. However …

This brief article provides an overview of the current state of the art in biological imaging
mass spectrometry using cluster time-of-flight secondary ion mass spectrometry (TOF …

Mass spectrometric imaging is a powerful tool to interrogate biological complexity. One such
technique, time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging, has been …

High-resolution images of cholesterol were obtained from Lymnaea stagnalis nervous tissue
using metal-assisted (MetA) time-of-flight secondary ion mass spectrometry (ToF-SIMS). The …

Lipids are an important class of biomolecules with many roles within cells and tissue. As
targets for study, they present several challenges. They are difficult to label, as many labels …

Investigation of the spatial distribution of lipids in cell membranes can lead to an improved
understanding of the role of lipids in biological function and disease. Time-of-flight …