Stress response elements, which mediate induction of the mouse heme oxygenase-1 (HO-1)
gene by several agents, resemble the binding site for the activator protein-1 (Jun/Fos), Maf …

We have shown previously that activation of the heme oxygenase-1 (ho-1) gene by hypoxia
in aortic smooth muscle cells is mediated by hypoxia-inducible factor-1 (HIF-1). In mutant …

Heme oxygenase (HO)-1 is a stress response protein, which confers cytoprotection against
oxidative injury and provides a vital function in maintaining tissue homeostasis. Molecular …

Jun and Fos (AP-1) transcription factors were recently proposed to mediate induction of the
mouse heme oxygenase-1 gene by different agents including heme and cadmium. In this …

Nrf2 regulates expression of genes encoding enzymes with antioxidant (eg. heme
oxygenase-1 (HO-1)) or xenobiotic detoxification (eg. NAD (P) H: quinone oxidoreductase …

Abstract Heme oxygenase‐1 (HO‐1) protects cells from various insults including oxidative
stress. Transcriptional activators, including the Nrf2/Maf heterodimer, have been the focus of …

Heme oxygenase (HO) is the rate-limiting enzyme in heme catabolism and its activity is
induced by many agents, including its substrate heme, heavy metals, UV radiation, and …

The heme oxygenase-1 (HO-1) enzyme catalyzes the rate-limiting reaction in the catabolism
of heme yielding products with pleiotropic, but ultimately, cytoprotective activities. High …

Oxidative stress activates the transcription factor NRF2, which in turn binds cis-acting
antioxidant response element (ARE) enhancers and induces expression of protective …

Mouse genomic fragments encoding heme oxygenase-1 (HO-1) were isolated from a
recombinant lambda library by in situ plaque hybridization. The mouse HO-1 gene …