Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits
Problematic alcohol use (PAU) is a leading cause of death and disability worldwide.
Although genome-wide association studies have identified PAU risk genes, the genetic …
Although genome-wide association studies have identified PAU risk genes, the genetic …
Genome-wide association study of maximum habitual alcohol intake in> 140,000 US European and African American veterans yields novel risk loci
Background Habitual alcohol use can be an indicator of alcohol dependence, which is
associated with a wide range of serious health problems. Methods We completed a genome …
associated with a wide range of serious health problems. Methods We completed a genome …
Genome-wide investigation of maximum habitual alcohol intake in US veterans in relation to alcohol consumption traits and alcohol use disorder
Importance Alcohol genome-wide association studies (GWASs) have generally focused on
alcohol consumption and alcohol use disorder (AUD); few have examined habitual drinking …
alcohol consumption and alcohol use disorder (AUD); few have examined habitual drinking …
Predicting risk for Alcohol Use Disorder using longitudinal data with multimodal biomarkers and family history: a machine learning study
S Kinreich, JL Meyers, A Maron-Katz… - Molecular …, 2021 - nature.com
Predictive models have succeeded in distinguishing between individuals with Alcohol use
Disorder (AUD) and controls. However, predictive models identifying who is prone to …
Disorder (AUD) and controls. However, predictive models identifying who is prone to …
Genetics of alcohol dependence
J Gelernter, HR Kranzler - Human genetics, 2009 - Springer
Alcohol dependence (AD), a genetically influenced phenotype, is extremely costly to
individuals and to society in the United States and throughout the world, contributing to …
individuals and to society in the United States and throughout the world, contributing to …
A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53
JC Wang, T Foroud, AL Hinrichs, NXH Le… - Molecular …, 2013 - nature.com
Several studies have identified genes associated with alcohol-use disorders (AUDs), but the
variation in each of these genes explains only a small portion of the genetic vulnerability …
variation in each of these genes explains only a small portion of the genetic vulnerability …
Genome-wide association study of alcohol dependence: significant findings in African-and European-Americans including novel risk loci
We report a GWAS of alcohol dependence (AD) in European-American (EA) and African-
American (AA) populations, with replication in independent samples of EAs, AAs and …
American (AA) populations, with replication in independent samples of EAs, AAs and …
Genetic studies of alcohol dependence in the context of the addiction cycle
Family, twin and adoption studies demonstrate clearly that alcohol dependence and alcohol
use disorders are phenotypically complex and heritable. The heritability of alcohol use …
use disorders are phenotypically complex and heritable. The heritability of alcohol use …
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals …
Association genome scanning can identify markers for the allelic variants that contribute to
vulnerability to complex disorders, including alcohol dependence. To improve the power …
vulnerability to complex disorders, including alcohol dependence. To improve the power …