Liposomes as carriers of hydrophilic small molecule drugs: strategies to enhance encapsulation and delivery

JO Eloy, MC de Souza, R Petrilli, JPA Barcellos… - Colloids and surfaces B …, 2014 - Elsevier
Although hydrophilic small molecule drugs are widely used in the clinic, their rapid
clearance, suboptimal biodistribution, low intracellular absorption and toxicity can limit their …

Trends and developments in liposome drug delivery systems

T Lian, RJY Ho - Journal of pharmaceutical sciences, 2001 - Elsevier
Since the discovery of liposomes or lipid vesicles derived from self‐forming enclosed lipid
bilayers upon hydration, liposome drug delivery systems have played a significant role in …

Stimulus-responsive liposomes for biomedical applications

AI Antoniou, S Giofrè, P Seneci, D Passarella… - Drug discovery today, 2021 - Elsevier
Liposomes are amphipathic lipidic supramolecular aggregates that are able to encapsulate
and carry molecules of both hydrophilic and hydrophobic nature. They have been widely …

[PDF][PDF] Liposomal drug delivery: a versatile platform for challenging clinical applications

A Madni, M Sarfraz, M Rehman… - … of Pharmacy & …, 2014 - frontierspartnerships.org
Liposomes are lipid based vesicular systems that offer novel platform for versatile drug
delivery to target cell. Liposomes were first reported by Bangham and his co-workers in …

Design of liposomal formulations for cell targeting

E Nogueira, AC Gomes, A Preto… - Colloids and surfaces B …, 2015 - Elsevier
Liposomes have gained extensive attention as carriers for a wide range of drugs due to
being both nontoxic and biodegradable as they are composed of substances naturally …

[HTML][HTML] Stimulus-responsive liposomes as smart nanoplatforms for drug delivery applications

PS Zangabad, S Mirkiani, S Shahsavari… - Nanotechnology …, 2018 - degruyter.com
Liposomes are known to be promising nanoparticles (NPs) for drug delivery applications.
Among the different types of self-assembled NPs, liposomes stand out for their non-toxic …

Small molecule therapeutic-loaded liposomes as therapeutic carriers: from development to clinical applications

JY Hwang, Z Li, XJ Loh - RSC advances, 2016 - pubs.rsc.org
While small hydrophilic therapeutic molecules have proved to be exceptionally effective in
curing diseases, their in vivo efficacy remains low. Small molecule therapeutics infused in …

Ligand-targeted liposomes

E Forssen, M Willis - Advanced drug delivery reviews, 1998 - Elsevier
Liposomes have gained increased attention as systemic drug delivery vehicles following
recent regulatory approvals of several vesicle-formulated drugs. These products have …

[HTML][HTML] Advances and challenges of liposome assisted drug delivery

L Sercombe, T Veerati, F Moheimani, SY Wu… - Frontiers in …, 2015 - frontiersin.org
The application of liposomes to assist drug delivery has already had a major impact on
many biomedical areas. They have been shown to be beneficial for stabilizing therapeutic …

Active methods of drug loading into liposomes: recent strategies for stable drug entrapment and increased in vivo activity

J Gubernator - Expert opinion on drug delivery, 2011 - Taylor & Francis
Introduction: The use of liposomes increases the therapeutic index of many drugs, and also
offers drug targeting and controlled release. The commercial impact of liposomes is …