Importance Criteria for preclinical Alzheimer disease (AD) propose β-amyloid (Aβ) plaques
to initiate neurodegeneration within AD-affected regions. However, some cognitively normal …

Importance The prevalence of pathologic conditions of the brain associated with Alzheimer
disease increases strongly with age. Little is known about the distribution and clinical …

Importance Assessing the ability of Alzheimer disease neuroimaging markers to predict
short-term cognitive decline among clinically normal (CN) individuals is critical for upcoming …

Importance The effect of β-amyloid (Aβ) accumulation on regional structural brain changes
in early stages of Alzheimer disease (AD) is not well understood. Objective To test the …

β-Amyloid (Aβ) plaque deposition and neurodegeneration within temporoparietal and
hippocampal regions may indicate increased risk of Alzheimer's disease (AD). This study …

Objective: To examine whether the association between clinical Alzheimer disease (AD)
diagnosis and neuropathology and the precision by which neuropathology differentiates …

Importance A National Institute on Aging and Alzheimer's Association workgroup proposed a
research framework for Alzheimer disease in which biomarker classification of research …

Importance Among cognitively normal individuals, elevated brain amyloid (defined by
cerebrospinal fluid assays or positron emission tomography regional summaries) can be …

Importance The accumulation of aggregated β-amyloid and tau proteins into plaques and
tangles is a central feature of Alzheimer disease (AD). While plaque and tangle …

Despite much attention to the use of biomarkers for predicting Alzheimer disease, little
information is available at the individual level. We used the population‐based Mayo Clinic …