Cilostazol improves the prognosis after hepatectomy in rats with sinusoidal obstruction syndrome

H Sugita, S Nakanuma, S Munesue… - Journal of …, 2024 - Wiley Online Library
Abstract Background and Aim Safe radical hepatectomy is important for patients with
colorectal liver metastases complicated by sinusoidal obstruction syndrome (SOS) after …

Clinically relevant model of oxaliplatin‐induced sinusoidal obstruction syndrome

R Toda, S Seo, Y Uemoto, K Morino… - Hepatology …, 2023 - Wiley Online Library
Aim Sinusoidal obstruction syndrome (SOS) induced by oxaliplatin‐including
chemotherapies (OXCx) is associated with impaired hepatic reserve and higher morbidity …

Sorafenib attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats through suppression of JNK and MMP-9

K Nakamura, E Hatano, M Narita… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: Sinusoidal obstruction syndrome (SOS) is a drug-induced liver
injury that occurs with oxaliplatin treatment and is associated with postoperative morbidity …

Inhibition of Vascular Endothelial Growth Factor Protects against the Development of Oxaliplatin-Induced Sinusoidal Obstruction Syndrome in Wild-Type but Not in …

S Knitter, G Duwe, AS Beierle, S Pesthy, PV Ritschl… - Cancers, 2022 - mdpi.com
Simple Summary For patients undergoing multimodal treatment for colorectal liver
metastases (CLM), the development of sinusoidal obstruction syndrome (SOS) as a side …

Regorafenib suppresses sinusoidal obstruction syndrome in rats

M Okuno, E Hatano, K Nakamura… - journal of surgical …, 2015 - Elsevier
Background Sinusoidal obstruction syndrome (SOS), a form of drug-induced liver injury
related to oxaliplatin treatment, is associated with postoperative morbidity after hepatectomy …

Hepatic regeneration is decreased in a rat model of sinusoidal obstruction syndrome

E Schiffer, JL Frossard, L Rubbia‐Brandt… - Journal of surgical …, 2009 - Wiley Online Library
Abstract Background and Objectives Oxaliplatin is a chemotherapeutic drug for colorectal
adenocarcinoma able to extend the indications for resection of colorectal liver metastases …

Sinusoidal obstruction syndrome in the animal model: influence on liver surgery

A Jafari, S Wehner, JC Kalff, S Manekeller - Langenbeck's archives of …, 2017 - Springer
Purpose In recent years, multimodal treatment approaches have led to an increased median
survival time of patients with colorectal liver metastases. In particular, this results from new …

Hepatic sinusoidal obstruction syndrome (SOS) reduces the effect of oxaliplatin in colorectal liver metastases

CPH Vreuls, MA Van Den Broek, A Winstanley… - …, 2012 - Wiley Online Library
Vreuls CPH, Van Den Broek MA, Winstanley A, Koek GH, Wisse E, Dejong CH, Olde Damink
SWM, Bosman FT & Driessen A (2012) Histopathology 61, 314–318 Hepatic sinusoidal …

The flavonoid monoHER prevents monocrotaline‐induced hepatic sinusoidal injury in rats

T Ezzat, MAJ van den Broek, N Davies… - Journal of Surgical …, 2012 - Wiley Online Library
Background Sinusoidal obstruction syndrome (SOS) occurs in 50–70% of patients after
oxaliplatin treatment for hepatic colorectal metastasis. SOS is associated with portal …

A phosphodiesterase III inhibitor protects rat liver from sinusoidal obstruction syndrome through heme oxygenase-1 induction

M Narita, E Hatano, I Ikai… - Annals of …, 2009 - journals.lww.com
Objective: The aim of study was to investigate pharmacological treatment for sinusoidal
obstruction syndrome (SOS). Background: SOS is associated with oxaliplatin-based …