Background: Long-term opioid treatment has been used extensively in treatment of chronic
low back pain (cLBP) in the last decades. However, there are serious limitations to the long …

Background Opioids as the strongest pain drugs are often used for chronic pain although
their long-term efficacy has not yet been clarified. In this longitudinal study, we compared the …

Objective. Several studies have shown that exposure to opioids for short or long periods
alters pain sensitivity. Little is known about changes in pain sensitivity during and after …

Objective The aim of this study was to compare the sensitivity to experimental pain of chronic
pain patients on opioid therapy vs chronic pain patients on non-opioid therapy and healthy …

Objective. Opioids are frequently prescribed for chronic low back pain (CLBP), but there are
broad individual differences in the benefits and risks of opioid therapy, including the …

Objectives: Quantitative sensory testing (QST) has been used to elucidate the peripheral
and central mechanisms that underlie changes in pain sensitivity associated with low back …

Methods In this randomized, placebo-controlled and double-blinded cross-over study, 50
patients with chronic low-back pain received a single oral dose of oxycodone 15 mg or …

Methods: Adults with opioid-treated CLBP (N= 107) completed questionnaires assessing
pain, pain symptoms, and psychological measures. CPM and TS were evaluated as …

This study employed quantitative sensory testing (QST) to evaluate pain responses in
chronic spinal pain patients at low risk and high risk for opioid misuse, with risk classification …

Preclinical studies have suggested that opioid exposure may induce a paradoxical decrease
in the nociceptive threshold, commonly referred as opioid-induced hyperalgesia (OIH) …