RATIONALE AND OBJECTIVES: MR imaging of the restricted diffusion of laser-polarized
3He gas provides unique insights into the changes in lung microstructure in emphysema …

Hyperpolarized 3 He gas allows the air spaces of the lungs to be imaged via MRI. Imaging of
restricted diffusion is addressed here, which allows the microstructure of the lung to be …

Hyperpolarized 3He gas MRI was used to form maps of the effective diffusivity of gas in
human lungs. Images of diffusion as well as spin density are presented from a study of 11 …

Diffusion MRI of hyperpolarized 3He shows that the apparent diffusion coefficient (ADC) of
3He gas is highly restricted in the normal lung and becomes nearly unrestricted in severe …

RATIONALE AND OBJECTIVES: Diffusion magnetic resonance imaging (MRI) with
hyperpolarized 3He gas is a powerful technique for probing the characteristics of the lung …

The study of lung emphysema dates back to the beginning of the 17th century. Nevertheless,
a number of important questions remain unanswered because a quantitative localized …

Recently, the apparent diffusion coefficient (ADC) of 3He has been measured in animal
models [1] and in humans [2, 3, 4]. Mugler et al.[2] measured the ADC in healthy volunteers …

Salerno et al, in this issue of Radiology (14), report a magnetic resonance (MR) imaging
technique that is sensitive to changes in peripheral lung structure associated with …

PURPOSE: To quantitatively evaluate hyperpolarized helium 3 (3He) diffusion magnetic
resonance (MR) images of the lung in patients with emphysema and to determine whether …

MRI-based study of 3He gas diffusion in lungs may provide important information on lung
microstructure. Lung acinar airways can be described in terms of cylinders covered with …