After myocardial infarction, ventricular geometry and function, as well as energy metabolism,
change markedly. In nonischemic heart failure, inhibition of xanthine oxidase (XO) improves …

Inhibition of xanthine oxidase (XO) in failing hearts improves cardiac efficiency by an
unknown mechanism. We hypothesized that this energetic effect is due to reduced oxidative …

Objective: Xanthine oxidase (XO) inhibitors enhance myofilament Ca2+ responsiveness of
normal rat myocardium. We examined whether this inotropic action is preserved or …

Reactive oxygen species, in particular superoxide, have been closely linked to the
underlying pathophysiology of ischemic cardiomyopathy: superoxide not only mediates …

Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with
volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of …

Oxidative stress is a hallmark of systemic illnesses, including heart failure. Nevertheless, the
overall importance of radical production in the heart remains conjectural; is it merely a …

Xanthine oxidase (XO) expression is increased in the failing heart, and animal studies in
rodents and dogs showed that XO inhibition with allopurinol can improve left ventricular (LV) …

Mellin et al. 1 report that short-and long-term xanthine oxidase (XO) inhibition with
allopurinol, initiated in rats with chronic heart failure due to myocardial infarction, improves …

The purine analog xanthine oxidase (XO) inhibitors (XOIs), allopurinol and oxypurinol, have
been reported to protect against heart failure secondary to myocardial infarction or rapid …

BACKGROUND: Oxidative stress is implicated in cardiac remodeling and failure. We tested
whether xanthine oxidase (XO) inhibition could decrease myocardial oxidative stress and …