Clinical studies with the fixed herbal combination product STW 5 (Iberogast®) have
indicated an efficacy comparable to metoclopramide (5-HT3 antagonist) and cisapride (5 …

Plants from Suriname (South-America) and several Annona species, including A. muricata,
A. ckerimolia, A. montana and A. glabra were screened for 5-HT1A receptor binding activity …

Four known alkyl 4‐hydroxybenzoates, ie, methyl 4‐hydroxybenzoate (1), ethyl 4‐
hydroxybenzoate (2), propyl 4‐hydroxybenzoate (3), and butyl 4‐hydroxybenzoate (4), were …

Abstract Serotonin receptor type 3 (5-HT 3 receptor) is a ligand-gated ion channel that is
expressed in the central nervous system (CNS) as well as in the peripheral nervous system …

Based on a known pharmacophore model for 5-HT6 receptor antagonists, a series of novel
extended derivatives of the N-arylsulfonyindole scaffold were designed and identified as a …

A series of 4-amino-5-chloro-2-methoxybenzoates and benzamides containing the 5-and 6-
isoquinuclidinyl system was synthesised and evaluated for binding to 5-HT3, 5-HT4 and D2 …

In our previous paper, we have reported that some 8‐alkoxy‐1, 3‐dimethyl‐1H‐purine‐2, 6
(3H, 7H)‐dione derivatives possessed high affinity and displayed agonistic activity for the …

In this investigation, 185 plant samples representing more than 30 plant families collected
from the Malaysian forests were assessed for their ability to inhibit specific radioligand …

This study describes the in vitro characterization of two potent and selective 5‐HT6 receptor
antagonists at the rat and human recombinant 5‐HT6 receptor. In binding assays with [3H] …

The pharmacological effect of a novel selective 5-HT4 receptor agonist, TS-951 (N-[endo-8-
(3-hydroxypropyl)-8-azabicyclo [3.2. 1] oct-3-yl]-1-isopropyl-2-oxo-1, 2-dihydro-3 …