Novel 1-(2-aminoethyl)-3-(arylsulfonyl)-1H-indoles were prepared. Binding assays indicated
they are 5-HT6 receptor ligands, among which N, N-dimethyl-N-{2-[3-(1-naphthylsulfonyl) …

Introduction. The human 5-HT7 receptor is a recently discovered member of the seven-
transmembrane G-protein-coupled receptor superfamily. 2 The most abundant isoform 5 …

The present studies have identified a series of diaminopyrimidines and diaminopyridines as
novel 5-HT7 receptor ligands. Three regiosiomeric classes of pyrimidines and four …

An analysis of the virtual combinatorial library was used for refining a pilot set of 34
derivatives and designing a targeted 38-member library of the arylamide and …

SB‐258585 (4‐Iodo‐N‐[4‐methoxy‐3‐(4‐methyl‐piperazin‐1‐yl)‐phenyl]‐
benzenesulphonamide) is a high affinity ligand at 5‐HT6 receptors. It displays over 100 fold …

A series of 3′-and 5′-carboxylated chalcones, 6-or 8-carboxylated flavones and 6-
carboxylated flavanones,-flavanols and-flavans were prepared. The compounds were tested …

A series of 2-alkyl-3-(1, 2, 3, 6-tetrahydropyridin-4-yl)-1H-indoles were synthesized and
evaluated for their 5-HT6 activity. The most potent agonist in this series was 5-chloro-2 …

1 In the presence of (−)− cyanopindolol (1.0 μm) and sumatriptan (1.0 μm), 0.5 nM [3H]‐
carboxamidotryptamine ([3H]‐5‐CT) labelled a single population of receptors in guinea‐pig …

A series of benzo [h][1, 6] naphthyridine and azepino [3, 2-c] quinoline derivatives were
prepared and evaluated to determine the necessary requirements for high affinity on the 5 …