During the transition from acute to chronic stages of recovery after spinal cord injury (SCI),
there is an evolving state of immunologic dysfunction that exacerbates the problems …

The field of neuroimmunology is rapidly advancing. There is a growing appreciation for
heterogeneity, both in inflammatory composition and region-specific inflammatory …

Traumatic spinal cord injury (SCI) in mammals causes widespread glial activation and
recruitment to the CNS of innate (eg neutrophils, monocytes) and adaptive (eg T and B …

Severe spinal cord injuries above mid-thoracic levels can lead to a potentially life-
threatening hypertensive condition termed autonomic dysreflexia, which is often triggered by …

Traumatic spinal cord injury (SCI) has widespread physiological effects beyond the
disruption of sensory and motor function, notably the loss of normal autonomic and …

Spinal cord injury (SCI) triggers profound changes in visceral and somatic targets of sensory
neurons below the level of injury. Despite this, little is known about the influence of injury to …

Spinal cord injury can have a range of debilitating effects, permanently impacting a patient's
quality of life. Initially thought to be an immune privileged site, the spinal cord is able to …

Infections impair neurological outcome and increase mortality after spinal cord injury (SCI).
Emerging data show that pathogens more easily infect individuals with SCI because SCI …

Peripheral nerve injury induces long-term pro-inflammatory responses in spinal cord glial
cells that facilitate neuropathic pain, but the identity of endogenous cells that resolve spinal …

Autonomic dysreflexia (AD) and neuropathic pain occur after severe injury to higher levels of
the spinal cord. Mechanisms underlying these problems have rarely been integrated in …