The pharmacological profile of celecoxib (CAS 169590-42-5, SC-58635), a specific
cyclooxygenase-2 (COX-2) inhibitor, was investigated. Celecoxib inhibited COX-2-mediated …

Five experimental models were developed in different groups of Wistar rats (N= 15) to study
selective COX-2-inhibitor NSAIDs such as celecoxib and rofecoxib, as follows:(1) dose …

The antinociceptive, anti-inflammatory, antipyretic effects along with gastric safety profile of
parecoxib, a novel, potent selective cyclooxygenase-2 inhibiting prodrug, and those of …

Aim: To evaluate the analgesic effects of 2 celecoxib derivatives and their inhibitory effects
on cyclooxygenase (COX). Methods: Four antinociceptive assays were used: the acetic acid …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective for the relief of pain and
inflammation, yet their use is tempered by the development of side effects, primarily in the …

NSAIDs are extensively used worldwide; nonetheless, they are associated with adverse
gastrointestinal (GI) effects. COX-2 inhibitors (coxibs) have been developed to reduce pain …

Background: Celecoxib, a nonsteroidal antiinflammatory drug exhibits its antiinflammatory
effect by selective inhibition of cyclooxygenase-2 (COX-2) enzyme. Its efficacy has been …

Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) and blocks prostaglandin
(PG) biosynthesis associated with inflammatory conditions. In a model of peripherally …

Background/Aims: Gastrointestinal (GI) disorders are common adverse reactions of
nonsteroidal anti-inflammatory drugs (NSAIDs). Loxoprofen is a representative NSAID …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequently prescribed
drugs, despite their well-established association with gastroduodenal injury. Recent …