Pharmacological profile of celecoxib, a specific cyclooxygenase-2 inhibitor
T Yoshino, A Kimoto, S Kobayashi… - …, 2005 - thieme-connect.com
The pharmacological profile of celecoxib (CAS 169590-42-5, SC-58635), a specific
cyclooxygenase-2 (COX-2) inhibitor, was investigated. Celecoxib inhibited COX-2-mediated …
cyclooxygenase-2 (COX-2) inhibitor, was investigated. Celecoxib inhibited COX-2-mediated …
Gastrointestinal damage induced by celecoxib and rofecoxib in rats
OM Laudanno, JA Cesolari, J Esnarriaga… - Digestive diseases and …, 2001 - Springer
Five experimental models were developed in different groups of Wistar rats (N= 15) to study
selective COX-2-inhibitor NSAIDs such as celecoxib and rofecoxib, as follows:(1) dose …
selective COX-2-inhibitor NSAIDs such as celecoxib and rofecoxib, as follows:(1) dose …
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor
SSV Padi, NK Jain, S Singh, SK Kulkarni - European journal of …, 2004 - Elsevier
The antinociceptive, anti-inflammatory, antipyretic effects along with gastric safety profile of
parecoxib, a novel, potent selective cyclooxygenase-2 inhibiting prodrug, and those of …
parecoxib, a novel, potent selective cyclooxygenase-2 inhibiting prodrug, and those of …
Evaluation of 2 celecoxib derivatives: analgesic effect and selectivity to cyclooxygenase‐2/11
Z LU, X XIONG, B ZHANG, G LIN, Y SHI… - Acta …, 2005 - Wiley Online Library
Aim: To evaluate the analgesic effects of 2 celecoxib derivatives and their inhibitory effects
on cyclooxygenase (COX). Methods: Four antinociceptive assays were used: the acetic acid …
on cyclooxygenase (COX). Methods: Four antinociceptive assays were used: the acetic acid …
Update on clinical developments with celecoxib, a new specific COX-2 inhibitor: what can we expect?
GS Geis - Scandinavian Journal of Rheumatology, 1999 - Taylor & Francis
Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective for the relief of pain and
inflammation, yet their use is tempered by the development of side effects, primarily in the …
inflammation, yet their use is tempered by the development of side effects, primarily in the …
Clinical pharmacology of celecoxib, a COX-2 selective inhibitor
K Antoniou, M Malamas, AA Drosos - Expert opinion on …, 2007 - Taylor & Francis
NSAIDs are extensively used worldwide; nonetheless, they are associated with adverse
gastrointestinal (GI) effects. COX-2 inhibitors (coxibs) have been developed to reduce pain …
gastrointestinal (GI) effects. COX-2 inhibitors (coxibs) have been developed to reduce pain …
[PDF][PDF] Clinical pharmacokinetic of celecoxib in healthy Thai volunteers
C Itthipanichpong, S Chompootaweep… - J Med Assoc …, 2005 - academia.edu
Background: Celecoxib, a nonsteroidal antiinflammatory drug exhibits its antiinflammatory
effect by selective inhibition of cyclooxygenase-2 (COX-2) enzyme. Its efficacy has been …
effect by selective inhibition of cyclooxygenase-2 (COX-2) enzyme. Its efficacy has been …
The analgesic actions of centrally administered celecoxib are mediated by endogenous opioids
RM Rezende, WGP Dos Reis, IDG Duarte, PP Lima… - Pain, 2009 - journals.lww.com
Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) and blocks prostaglandin
(PG) biosynthesis associated with inflammatory conditions. In a model of peripherally …
(PG) biosynthesis associated with inflammatory conditions. In a model of peripherally …
Efficacy and safety of the selective cyclooxygenase-2 inhibitor celecoxib in the treatment of rheumatoid arthritis and osteoarthritis in Japan
C Sakamoto, S Soen - Digestion, 2010 - karger.com
Background/Aims: Gastrointestinal (GI) disorders are common adverse reactions of
nonsteroidal anti-inflammatory drugs (NSAIDs). Loxoprofen is a representative NSAID …
nonsteroidal anti-inflammatory drugs (NSAIDs). Loxoprofen is a representative NSAID …
Celecoxib, a selective cyclooxygenase-2 inhibitor for the treatment of rheumatoid arthritis and osteoarthritis
MM Goldenberg - Clinical therapeutics, 1999 - Elsevier
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequently prescribed
drugs, despite their well-established association with gastroduodenal injury. Recent …
drugs, despite their well-established association with gastroduodenal injury. Recent …