In vitro potency evaluations of various piperacillin/tazobactam generic products compared with the contemporary branded (Zosyn®, Wyeth) formulation

RN Jones, TR Fritsche, GJ Moet - Diagnostic microbiology and infectious …, 2008 - Elsevier
Twenty-three generic intravenous piperacillin/tazobactam products were compared for in
vitro activity to the branded formulation (Zosyn®, Wyeth, Philadelphia, PA) by disk diffusion …

Expanded studies of piperacillin/tazobactam formulations: variations among branded product lots and assessment of 46 generic lots

GJ Moet, AA Watters, HS Sader, RN Jones - Diagnostic microbiology and …, 2009 - Elsevier
The experience with analyzing the potency of piperacillin/tazobactam generic formulations
by a precise multiorganism in vitro assay was expanded to 46 lots (29 manufacturers, 17 …

Pharmacokinetic and pharmacodynamic evaluation of two dosing regimens for piperacillin‐tazobactam

MK Kim, B Capitano, HM Mattoes… - … : The Journal of …, 2002 - Wiley Online Library
Study Objective. To compare the pharmacokinetic and pharmacodynamic profiles of two
dosing regimens for piperacillin‐tazobactam against commonly encountered pathogens …

Pharmacokinetic and pharmacodynamic profile of high dose extended interval piperacillin–tazobactam

MK Kim, D Xuan, R Quintiliani… - Journal of …, 2001 - academic.oup.com
A multiple-dose, open-labelled, randomized, two period crossover human volunteer study
was performed (i) to describe the pharmacokinetic profile and safety profile of piperacillin …

Comparison of fixed concentration and fixed ratio options for testing susceptibility of gram-negative bacilli to piperacillin and piperacillin/tazobactam

MA Pfaller, AL Barry, PC Fuchs, EH Gerlach… - European Journal of …, 1992 - Springer
Piperacillin combined with tazobactam was tested at both a fixed ratio (8: 1) and fixed
tazobactam concentration (4 µg/ml) against 2,685 consecutively isolated gram-negative …

Pharmacokinetic evaluation of piperacillin-tazobactam

Y Hayashi, JA Roberts, DL Paterson… - Expert opinion on drug …, 2010 - Taylor & Francis
Importance of the field: Piperacillin-tazobactam is a frequently prescribed intravenous
antibiotic for moderate to severe infections used in hospital settings because of its broad …

Comparative pharmacokinetic and pharmacodynamic profile of piperacillin/tazobactam 3.375 G Q4H and 4.5 G Q6H

HM Mattoes, B Capitano, MK Kim, D Xuan… - Chemotherapy, 2002 - karger.com
When piperacillin/tazobactam has been used to treat hospitalized patients with serious
infections, including nosocomial pneumonia caused by Pseudomonas aeruginosa, it has …

Pharmacokinetics and pharmacodynamics of two multiple-dose piperacillin-tazobactam regimens

DJ Occhipinti, SL Pendland… - Antimicrobial agents …, 1997 - Am Soc Microbiol
The pharmacokinetics and pharmacodynamics of two multiple-dose regimens of piperacillin-
tazobactam (3.375 g every 6 h and 4.5 g every 8 h) were evaluated at steady state for 12 …

Steady-state pharmacokinetics and pharmacodynamics of piperacillin/tazobactam administered by prolonged infusion in hospitalised patients

KM Shea, SC Cheatham, MF Wack, DW Smith… - International journal of …, 2009 - Elsevier
The objective of this study was to evaluate the steady-state pharmacokinetics and
pharmacodynamics of piperacillin/tazobactam, administered by prolonged infusion, in …

Potency and antimicrobial spectrum update for piperacillin/tazobactam (2000): emphasis on its activity against resistant organism populations and generally untested …

DM Johnson, DJ Biedenbach, RN Jones - Diagnostic microbiology and …, 2002 - Elsevier
The in vitro activity of piperacillin/tazobactam and several comparison broad-spectrum
compounds was assessed against recent clinical isolates of Gram-positive and-negative …