Bauer A, Postrach J, Thormann M, Blanck S, Faber C, Wintersperger B, Michel S, Abicht J‐
M, Christ F, Schmitz C, Schmoeckel M, Reichart B, Brenner P. First experience with …

OBJECTIVES: Transplantation is limited by a lack of human organ donors. Organs derived
from animals, most likely the pig, represent a potential solution to this problem. For the heart …

Xenotransplantation is a potential solution for the worldwide persisting donor organ
shortage. However, immunological and physiological barriers need to be overcome before …

Significant progress in understanding and overcoming cardiac xenograft rejection using a
clinically relevant large animal pig-to-baboon model has accelerated in recent years. This …

If pig hearts could be transplanted successfully into patients with end-stage cardiac failure,
the critical shortage of hearts from deceased human donors would be overcome. The …

Cardiac xenotransplantation from swine has been proposed to “bridge the gap” in supply for
heart failure patients requiring transplantation. Recent preclinical success using genetically …

Introduction Orthotopic cardiac xenotransplantation has seen notable improvement, leading
to the first compassionate use in 2022. However, it remains challenging to define the clinical …

For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

Background. Animal organs could satisfy the demand for solid organ transplants, which
currently exceeds the limited human donor supply. Hyperacute rejection, the initial immune …

Background The absolute shortage of donors compared with patients requiring
transplantation is currently an unsolved problem, and the only possible solution may be …