The selective ubiquitination of proteins by ubiquitin E3 ligases plays an important regulatory
role in control of cell differentiation, growth, and transformation and their dysregulation is …

Background Epithelial-mesenchymal transition (EMT) is a crucial step for solid tumor
progression and plays an important role in cancer invasion and metastasis. RNF8 is an …

To identify novel oncogenic E3 ubiquitin ligases as anticancer targets, we screened an E3
ubiquitin ligase siRNA library containing siRNA pools against 555 individual E3s using the …

The tumor suppressor P53 plays critical role in preventing cancer. P53 is rarely mutated and
remains functional in luminal-type breast cancer (1). According to current knowledge, wild …

Breast cancer causes the No. 1 women cancer prevalence and the No. 2 women cancer
mortality worldwide. Nuclear receptor/transcriptional factor signaling is aberrant and plays …

The ubiquitin ligase ring finger protein 5 (RNF5) has previously been associated with the
development of breast cancer. Patients with breast cancer and high RNF5 expression have …

Protein ubiquitination by E3 ubiquitin ligases plays an important role in cancer development.
In this study, we provide experimental evidence that a RING-finger-containing protein …

RNF11 (Ring Finger Protein 11) is a 154 amino-acid long protein that contains a RING-H2
domain, whose sequence has remained substantially unchanged throughout vertebrate …

Protein ubiquitination mediated by ubiquitin ligases plays a very important role in a wide
spectrum of biological processes including development and disease pathogenesis. RING …

Cell death and survival signaling pathways have opposed but fundamental functions for
various cellular processes and maintain cell homeostasis through cross talk. Here we report …