From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal
organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical …

ABSTRACT Introduction: Systemic sclerosis (SSc) is a complex autoimmune connective
tissue disease characterized by chronic and progressive tissue and organ fibrosis with …

Although infectiological stimuli, environmental factors and genotypic features are known to
contribute to the initiation and perpetuation of systemic sclerosis (SSc), its etiology still …

Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by
severe and often progressive cutaneous and visceral fibrosis, pronounced alterations in the …

Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …

Systemic sclerosis (SSc) is a systemic, immune-mediated chronic disorder characterized by
small vessel alterations and progressive fibrosis of the skin and internal organs. The …

Systemic sclerosis (SSc) is a complex disease characterized by early microvascular
abnormalities, immune dysregulation and chronic inflammation, and subsequent fibrosis of …

Systemic sclerosis (SSc) is a complex autoimmune disease in which immune activation,
vasculopathy, and extensive fibrosis of the skin and internal organs are among the principal …

Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized
by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction …

Systemic sclerosis (SSc), also known as scleroderma, is a rare connective tissue disease
characterized by vascular and immune dysfunction, leading to fibrosis that can damage …