DNA damage increases p53 protein levels and activates transcription of the p21 gene. The
p21 protein binds to and inhibits cdk2 kinase, causing G1 arrest. Here, we have investigated …

Overexpression of wild-type p53 prevents cells from entering the S phase of the cell cycle.
The amino-terminal transactivation region of p53 is phosphorylated by several protein …

Phosphorylation at serine 15 of the human p53 tumor suppressor protein is induced by DNA
damage and correlates with accumulation of p53 and its activation as a transcription factor …

The growth suppressor protein p53 and the protein kinase CK2 are both implicated in
cellular growth regulation. We previously found that p53 binds to protein kinase CK2 via its …

Rat fibroblasts transformed by a temperature-sensitive mutant of murine p53 undergo a
reversible growth arrest in G 1 at 32.5 C, the temperature at which p53 adopts a wild-type …

The loss of p53 induces spontaneous tumors in mice, and p53 mutations are found in
approximately 50% of human tumors. These tumors are generally caused by a number of …

p53 is one of the most important regulators of cell proliferation and differentiation and of
programmed cell death, triggering growth arrest and/or apoptosis in response to different …

Human DNA-PK is a nuclear, serine/threonine protein kinase that, when activated by DNA,
phosphorylates several DNA-binding substrates, including the tumor suppressor protein …

p21 is a member of the Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors that
includes p21, p27, and p57. Recent studies have suggested that Cdk2 activity may promote …

The tumor suppressor p53 regulates transcription positively and negatively, depending on
the target gene. Whereas p53 induces transcription through direct interaction with promoter …