Analyzing the potential biological determinants of autism spectrum disorder: from neuroinflammation to the kynurenine pathway

R Savino, M Carotenuto, AN Polito, S Di Noia… - Brain sciences, 2020 - mdpi.com
Autism Spectrum Disorder (ASD) etiopathogenesis is still unclear and no effective
preventive and treatment measures have been identified. Research has focused on the …

Altered kynurenine pathway metabolism in autism: implication for immune‐induced glutamatergic activity

CK Lim, MM Essa, R de Paula Martins… - Autism …, 2016 - Wiley Online Library
Dysfunction of the serotoninergic and glutamatergic systems is implicated in the
pathogenesis of autism spectrum disorder (ASD) together with various neuroinflammatory …

Maternal inflammation with elevated kynurenine metabolites is related to the risk of abnormal brain development and behavioral changes in autism spectrum disorder

Y Murakami, Y Imamura, Y Kasahara, C Yoshida… - Cells, 2023 - mdpi.com
Several studies show that genetic and environmental factors contribute to the onset and
progression of neurodevelopmental disorders. Maternal immune activation (MIA) during …

A proposed mechanism for autism: an aberrant neuroimmune response manifested as a psychiatric disorder

MR Buehler - Medical hypotheses, 2011 - Elsevier
Autism, an incurable neurodevelopmental brain disorder, is a complex psychopathology in
which the affected individual cannot effectively self-regulate their sensory inputs toward …

Kynurenine pathway and autism spectrum phenotypes: an investigation among adults with autism spectrum disorder and their first-degree relatives

B Carpita, B Nardi, L Palego, IM Cremone… - CNS …, 2023 - cambridge.org
Background Increasing literature highlighted alterations of tryptophan (TRP) metabolism and
kynurenine (KYN) pathway in children with autism spectrum disorder (ASD). However, no …

Inflammation and mitochondrial dysfunction in autism spectrum disorder

M Gevezova, V Sarafian, G Anderson… - CNS & Neurological …, 2020 - ingentaconnect.com
Autism Spectrum Disorders (ASD) is a severe childhood psychiatric condition with an array
of cognitive, language and social impairments that can significantly impact family life. ASD is …

[HTML][HTML] Novel probable glance at inflammatory scenario development in autistic pathology

AA Harutyunyan, HA Harutyunyan… - Frontiers in …, 2021 - frontiersin.org
Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social
communication and restricted-repetitive patterns of behavior, interests, or activities. ASD is …

Kynurenine pathway in autism spectrum disorders in children

V Bryn, R Verkerk, OH Skjeldal, OD Saugstad… - …, 2018 - karger.com
Background: There is increasing evidence that altered immune responses play a role in the
pathogenesis of autism spectrum disorders (ASD), together with dysfunction of the …

Impact of IDO activation and alterations in the kynurenine pathway on hyperserotonemia, NAD+ production, and AhR activation in autism spectrum disorder

JM Launay, R Delorme, C Pagan, J Callebert… - Translational …, 2023 - nature.com
Hyperserotonemia is the most replicated biochemical anomaly associated with autism
spectrum disorder (ASD) and has been reported in 35–46% of individuals with ASD …

Peripheral and central inflammation in autism spectrum disorders

AM Depino - Molecular and Cellular Neuroscience, 2013 - Elsevier
Recent reports have given a central role to environmental factors in the etiology of autism
spectrum disorders (ASD). However, most proposed perinatal factors seem to converge into …