Opinion statement Gastroesophageal reflux disease (GERD) is currently defined as a
condition that develops when the reflux of stomach contents causes recurrent symptoms …

Background Bowel symptoms have been associated with non‐erosive reflux disease
(NERD). However, their role in functional heartburn (FH) has not been established. Aims To …

Background Nonerosive gastroesophageal reflux disease (NERD) patients frequently show
features of the irritable bowel syndrome (IBS). Aims To investigate the prevalence and …

Background By means of 24 h multi-channel intraluminal impedance and pH recording
(MII/pH), patients with heartburn and normal upper gastrointestinal endoscopy findings can …

Thus far, what constitutes refractory gastroesophageal reflux disease (GERD) remains an
area of intense controversy. Many investigators believe that only GERD patients who exhibit …

Methods Seventy patients with suspected symptoms of GERD (such as heartburn, acid
regurgitation, non-cardiac chest pain, globus and chronic cough) were enrolled. All patients …

AIM: To clarify the pathogenesis of gastroesophageal reflux disease symptoms in non-
erosive reflux disease (NERD) patients. METHODS: Thirty-five NERD patients with …

Methods Clinical and endoscopic data, HRM and multichannel intraluminal impedance-pH
(MII-pH) studies performed off proton pump inhibitor therapy in patients with esophageal …

Purpose: Refluxate with a pH> 4 (“non-acid” reflux, NAR) cannot be detected on standard
esophageal pH monitoring. However this can be overcome by the use of Multichannel …

Background An international group of experts evaluated and revised recommendations for
ambulatory reflux monitoring for the diagnosis of gastro‐esophageal reflux disease (GERD) …