The cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein is a cAMP-
activated anion channel that is critical for regulating fluid and ion transport across the …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause
the inherited disorder cystic fibrosis (CF). Lung disease is the major cause of CF morbidity …

Cystic fibrosis (CF) is an inherited disorder caused by a deleterious mutation in the cystic
fibrosis transmembrane conductance regulator (CFTR) gene. Given that the CFTR protein is …

Chronic obstructive lung disease starting in the first months of life remains the major cause
of morbidity and mortality in patients with cystic fibrosis (CF). The discovery of the cystic …

In cystic fibrosis (CF) the ability of the CF transmembrane conductance regulator (CFTR)
protein to mediate chloride and water transport is disrupted. While much progress has been …

Cystic fibrosis (CF) remains the most common fatal hereditary lung disease. The discovery of
the cystic fibrosis transmembrane conductance regulator (CFTR) gene 25 years ago set the …

Since the 1989 discovery that mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) gene cause cystic fibrosis (CF), there has been substantial progress …

Cystic Fibrosis (CF) is a genetic disease caused by mutations in the gene encoding the
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel. Currently, more …

Defective epithelial ion transport is the hallmark of the life-limiting genetic disease cystic
fibrosis (CF). This abnormality is caused by mutations in the cystic fibrosis transmembrane …

In patients with cystic fibrosis (CF), it is extraordinary that defects in a chloride channel
scarcely expressed in airway epithelia, produce severe bronchial infections and eventually …