Sepsis is a life-threatening systemic inflammatory condition triggered as a result of an
excessive host immune response to infection. In the past, immunomodulators have …

Acute lung injury is an inflammatory condition developed after severe sepsis in response to
excessive secretion of pro-inflammatory cytokines. Doxycycline is widely reported to …

To assess the efficacy of clarithromycin as an immunomodulator in experimental sepsis with
Escherichia coli, acute pyelonephritis was induced after ligation of the right ureter and …

Experimental and clinical studies in sepsis indicate that antibiotic therapy may induce the
release of endotoxin (LPS) from the outer membrane of gram-negative bacteria and …

Macrolide antibacterials inhibit the production of various cytokines and the migration of
inflammatory cells. These anti-inflammatory actions of macrolides may be beneficial in …

Differing antibiotic regimens can influence both survival and the inflammatory state in sepsis.
We investigated whether the addition and/or type of antimicrobial agent could effect mortality …

Despite intensive efforts to increase our knowledge of the inflammatory pathways involved in
the pathogenesis of sepsis, several clinical trials of agents aimed at modulating the immune …

Azithromycin has been shown to preferentially distribute to infection loci. Due to the potential
contribution of phagocytes as transporters of drug to these sites, there has been some …

Sepsis is a complex medical condition characterized by a systemic inflammatory response in
the setting of infection. We hypothesized that combining antibiotics plus an …

Acute respiratory distress syndrome following an acute lung injury (ALI) is a life threatening
inflammatory condition predominantly characterized by vascular protein leakage, neutrophil …