[HTML][HTML] Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand: Mechanistic studies on antitumor action
J Kasparkova, O Novakova, V Marini, Y Najajreh… - Journal of Biological …, 2003 - ASBMB
A paradigm for the structure-pharmacological activity relationship of bifunctional platinum
antitumor drugs is that the trans isomer of antitumor cisplatin (transplatin) is clinically …
antitumor drugs is that the trans isomer of antitumor cisplatin (transplatin) is clinically …
Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonleaving groups
V Brabec, K Neplechova, J Kasparkova… - Journal of Biological …, 2000 - Springer
Recent findings that novel trans-dichloroplatinum (II) complexes exhibit antitumor activity
violate the classical structure-activity relationships of platinum (II) complexes. These novel …
violate the classical structure-activity relationships of platinum (II) complexes. These novel …
DNA interactions of new cytotoxic tetrafunctional dinuclear platinum complex trans, trans-[{PtCl2 (NH3)} 2 (piperazine)]
V Brabec, P Christofis, M Slámová… - Biochemical …, 2007 - Elsevier
A new tetrafunctional dinuclear platinum complex trans, trans-[{PtCl2 (NH3)} 2 (piperazine)]
with sterically rigid linking group was designed, synthesized and characterized. In this novel …
with sterically rigid linking group was designed, synthesized and characterized. In this novel …
DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand
R Prokop, J Kasparkova, O Novakova, V Marini… - Biochemical …, 2004 - Elsevier
The global modification of mammalian and plasmid DNAs by novel platinum compounds,
trans-[PtCl2 (NH3)(Am)], where Am= 2-methylbutylamine or sec-butylamine was …
trans-[PtCl2 (NH3)(Am)], where Am= 2-methylbutylamine or sec-butylamine was …
DNA Binding by Antitumor trans-[PtCl2(NH3)(thiazole)]. Protein Recognition and Nucleotide Excision Repair of Monofunctional Adducts
J Kasparkova, O Novakova, N Farrell, V Brabec - Biochemistry, 2003 - ACS Publications
Antitumor effects of cis-diamminedichloroplatinum (II)(cisplatin) and the clinical inactivity of
its trans isomer (transplatin) have been considered a paradigm for the classical structure …
its trans isomer (transplatin) have been considered a paradigm for the classical structure …
Effect of geometric isomerism in dinuclear platinum antitumor complexes on DNA interstrand cross-linking
J Kašpárková, O Nováková, O Vrána, N Farrell… - Biochemistry, 1999 - ACS Publications
The requirement for novel platinum antitumor drugs led to the synthesis of dinuclear
bisplatinum complexes. To understand the molecular mechanisms underlying the biological …
bisplatinum complexes. To understand the molecular mechanisms underlying the biological …
DNA–protein cross‐linking by trans ‐[PtCl 2 ( E‐ iminoether) 2 ]. A concept for activation of the trans …
O Novakova, J Kasparkova, J Malina… - Nucleic acids …, 2003 - academic.oup.com
The structure–pharmacological activity relationships generally accepted for antitumor
platinum compounds stressed the necessity for the cis‐[PtX 2 (amine) 2] structure while the …
platinum compounds stressed the necessity for the cis‐[PtX 2 (amine) 2] structure while the …
DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell …
J Kasparkova, V Marini, Y Najajreh, D Gibson… - Biochemistry, 2003 - ACS Publications
The global modification of mammalian and plasmid DNAs by novel platinum compounds, cis-
or trans-[PtCl2 (NH3)(Am)], where Am= NH3, nonplanar heterocycle piperidine, piperazine …
or trans-[PtCl2 (NH3)(Am)], where Am= NH3, nonplanar heterocycle piperidine, piperazine …
DNA interactions of bifunctional dinuclear platinum (II) antitumor agents
R Žaludová, A Žákovská, J Kašpárková… - European Journal of …, 1997 - Wiley Online Library
Modifications of natural DNA in a cell‐free medium by dinuclear bisplatinum complexes with
equivalent coordination spheres, represented by the general formula [{trans‐PtCl (NH3) 2} 2 …
equivalent coordination spheres, represented by the general formula [{trans‐PtCl (NH3) 2} 2 …
DNA Modifications by Antitumortrans-[PtCl2 (E-Iminoether) 2]
R Žaludová, A Žákovská, J Kašpárkova… - Molecular …, 1997 - ASPET
Recent findings that an analogue of clinically ineffective transplatin, trans-[PtCl2 (E-
iminoether) 2], exhibits antitumor activity has helped reevaluation of the empirical structure …
iminoether) 2], exhibits antitumor activity has helped reevaluation of the empirical structure …
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