Controlled release of a therapeutic peptide in sprayable surgical sealant for prevention of postoperative abdominal adhesions

M Erdi, MS Saruwatari, S Rozyyev, C Acha… - … Applied Materials & …, 2023 - ACS Publications
Formation of asymmetric, rigid scar tissue known as surgical adhesions is caused by
traumatic disruption of mesothelial-lined surfaces in surgery. A widely adopted prophylactic …

Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue

H Yuk, J Wu, TL Sarrafian, X Mao, CE Varela… - Nature biomedical …, 2021 - nature.com
Tissue adhesives do not normally perform well on tissues that are covered with blood or
other bodily fluids. Here we report the design, adhesion mechanism and performance of a …

Novel wound sealants: Biomaterials and applications

HT Peng, PN Shek - Expert review of medical devices, 2010 - Taylor & Francis
Wound sealants provide an excellent alternative for closing surgical and non-surgical
wounds, as well as stopping external bleeding for prehospital trauma injuries. Numerous …

An endoscopically compatible fast-gelation powder forms Janus-adhesive hydrogel barrier to prevent postoperative adhesions

Y Jia, J Feng, Z Feng, J Liu, Y Yang… - Proceedings of the …, 2023 - National Acad Sciences
Postoperative adhesions occur widely in various tissues, bringing the risk of secondary
surgery and increased medical burden. Hydrogel barriers with Janus-adhesive ability can …

Engineered hemostatic biomaterials for sealing wounds

H Montazerian, E Davoodi, A Baidya… - Chemical …, 2022 - ACS Publications
Hemostatic biomaterials show great promise in wound control for the treatment of
uncontrolled bleeding associated with damaged tissues, traumatic wounds, and surgical …

[HTML][HTML] Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage

G Bao, Q Gao, M Cau, N Ali-Mohamad… - Nature …, 2022 - nature.com
Non-compressible hemorrhage is an unmet clinical challenge that accounts for high
mortality in trauma. Rapid pressurized blood flows under hemorrhage impair the function …

A double crosslinking adhesion mechanism for developing tough hydrogel adhesives

J Han, J Park, R Bhatta, Y Liu, Y Bo, J Zhou, H Wang - Acta Biomaterialia, 2022 - Elsevier
Tough hydrogel adhesives that consist of a robust gel network and can strongly adhere to
wet tissues have shown great promise as the next generation of bioadhesives. While a …

An injectable and instant self-healing medical adhesive for wound sealing

F Sun, Y Bu, Y Chen, F Yang, J Yu… - ACS applied materials & …, 2020 - ACS Publications
Designing versatile functional medical adhesives with injectability, self-healing, and strong
adhesion is of great significance to achieve desirable therapeutic effects for promoting …

Sequential‐Crosslinking Fibrin Glue for Rapid and Reinforced Hemostasis

L Yu, Z Liu, Z Tong, Y Ding, Z Qian, W Wang… - Advanced …, 2024 - Wiley Online Library
Achieving hemostasis effectively is essential for surgical success and excellent patient
outcomes. However, it is challenging to develop hemostatic adhesives that are fast‐acting …

A biodegradable and biocompatible gecko-inspired tissue adhesive

A Mahdavi, L Ferreira, C Sundback… - Proceedings of the …, 2008 - National Acad Sciences
There is a significant medical need for tough biodegradable polymer adhesives that can
adapt to or recover from various mechanical deformations while remaining strongly attached …