The epigenetic landscape of differentiated thyroid cancer

SL Asa, S Ezzat - Molecular and cellular endocrinology, 2018 - Elsevier
Differentiated thyroid carcinoma of follicular cell-derivation is the most common endocrine
neoplasm with a rapidly increasing incidence. The majority represent papillary carcinomas; …

Perspective: lessons learned from molecular genetic studies of thyroid cancer—insights into pathogenesis and tumor-specific therapeutic targets

JA Fagin - Endocrinology, 2002 - academic.oup.com
Thyroid cancer derived from follicular cells is the most common endocrine malignancy. The
past decade has seen progress in our understanding of the pathogenesis of the various …

Molecular and genetic markers of follicular-cell thyroid cancer: etiology and diagnostic and therapeutic opportunities

N Goyal, D Setabutr, J Abdulghani… - Impact of Genetic Targets …, 2013 - Springer
Thyroid cancer has an increasing incidence in the US population and worldwide, with 95%
of the cancers being of follicular cell origin—papillary, follicular, or anaplastic thyroid …

[HTML][HTML] Molecular genetics of follicular-derived thyroid cancer

E Macerola, AM Poma, P Vignali, A Basolo, C Ugolini… - Cancers, 2021 - mdpi.com
Simple Summary Thyroid tumors that derive from follicular cells are not a homogeneous
entity, showing variable morphological appearance and different degrees of differentiation …

Epigenetic dysregulation in thyroid neoplasia

T Kondo, SL Asa, S Ezzat - Endocrinology and metabolism clinics of North …, 2008 - Elsevier
Gain-of-function mutations in oncogenes have aided our understanding of the molecular
mechanisms of thyroid carcinogenesis. Mutations or deletions cause inactivation of tumor …

Well differentiated follicular thyroid neoplasia: impact of molecular and technological advances on detection, monitoring and treatment

AG Gianoukakis, SM Giannelli, WA Salameh… - Molecular and cellular …, 2011 - Elsevier
Our understanding of the molecular mechanisms responsible for follicular thyroid cell
oncogenesis has been advanced significantly in recent years. Specific genetic alterations …

Genetic considerations in thyroid cancer

KN Patel, B Singh - Cancer control, 2006 - journals.sagepub.com
Background Recent molecular studies have described a number of abnormalities
associated with the progression and dedifferentiation of thyroid carcinoma. These distinct …

Genomic hallmarks of thyroid neoplasia

TJ Giordano - Annual Review of Pathology: Mechanisms of …, 2018 - annualreviews.org
The genomic landscape of thyroid cancers that are derived from follicular cells has been
substantially elucidated through the coordinated application of high-throughput genomic …

[HTML][HTML] Thyroid carcinoma: phenotypic features, underlying biology and potential relevance for targeting therapy

J Hu, IJ Yuan, S Mirshahidi, A Simental, SC Lee… - International journal of …, 2021 - mdpi.com
Thyroid carcinoma consists a group of phenotypically heterogeneous cancers. Recent
advances in biological technologies have been advancing the delineation of genetic …

Pathogenesis of cancers derived from thyroid follicular cells

JA Fagin, GP Krishnamoorthy, I Landa - Nature reviews Cancer, 2023 - nature.com
The genomic simplicity of differentiated cancers derived from thyroid follicular cells offers
unique insights into how oncogenic drivers impact tumour phenotype. Essentially, the main …