Risk factors for the development of specific noncardiovascular adverse effects associated with amiodarone

JE Tisdale, SL Follin, A Ordelova… - The Journal of Clinical …, 1995 - Wiley Online Library
Noncardiovascular adverse effects associated with amiodarone result in substantial
morbidity. Adverse effects involving the skin, liver, thyroid, and lungs have been reported in …

Antiarrhythmic agents and the risk of malignant neoplasm of liver and intrahepatic bile ducts

YP Lim, CL Lin, YN Lin, WC Ma, WC Chen, DZ Hung… - PLoS …, 2015 - journals.plos.org
Background The objective of this study was to determine the association between the use of
antiarrhythmic agents and the risk of malignant neoplasm of liver and intrahepatic bile ducts …

[HTML][HTML] Fatal acute liver failure with intravenous amiodarone: a case report and literature review

V Gayam, M Khalid, S Dahal, P Garlapati… - Gastroenterology …, 2018 - ncbi.nlm.nih.gov
Amiodarone is a drug which frequently causes elevated transaminases. However, acute
liver failure has been rarely reported. Here, we present a case of fatal acute liver failure …

Pleiotropic actions of amiodarone: still puzzling after half a century

J Heijman, D Dobrev - Naunyn-Schmiedeberg's Archives of Pharmacology, 2013 - Springer
Amiodarone was developed in the early 1960s based on extracts from the Khella plant and
was initially used as a coronary dilator for the treatment of angina pectoris (Singh 2008). In …

[HTML][HTML] Acute hepatitis after amiodarone infusion

P Fonseca, A Dias, H Gonçalves… - World Journal of …, 2015 - ncbi.nlm.nih.gov
Acute hepatitis is a very rare, but potentially fatal, adverse effect of intravenous amiodarone.
We present a case of an 88-year-old man with history of ischemic dilated cardiomyopathy …

Establishment of a mouse model for amiodarone‐induced liver injury and analyses of its hepatotoxic mechanism

S Takai, S Oda, K Tsuneyama, T Fukami… - Journal of Applied …, 2016 - Wiley Online Library
Drug‐induced liver injury (DILI) is the most frequent cause of post‐marketing warnings and
withdrawals. Amiodarone (AMD), an antiarrhythmic, presents a risk of liver injury in humans …

Population-level incidence and risk factors for pulmonary toxicity associated with amiodarone

CA Jackevicius, A Tom, V Essebag… - The American journal of …, 2011 - Elsevier
Estimates from clinical trials and small observational studies of the incidence of pulmonary
toxicity (PT) associated with amiodarone range from 1% to 10%. We report a unique study of …

Amiodarone-induced liver injury and cirrhosis

J Buggey, M Kappus, AS Lagoo… - ACG case reports …, 2015 - journals.lww.com
We present a case report of an 80-year-old woman with volume overload thought initially to
be secondary to heart failure, but determined to be amiodarone-induced acute and chronic …

Amiodarone and the risk of cancer: a nationwide population‐based study

VYF Su, YW Hu, KT Chou, SM Ou, YC Lee, EYH Lin… - Cancer, 2013 - Wiley Online Library
BACKGROUND: In postmarketing surveillance, the US Food and Drug Administration has
reported the development of lung masses, thyroid cancer, and skin cancer after amiodarone …

Adverse effects of low dose amiodarone: a meta-analysis

VR Vorperian, TC Havighurst, S Miller… - Journal of the American …, 1997 - jacc.org
Objectives. We sought to assess the odds of experiencing adverse effects with low dose
amiodarone therapy compared with placebo. Background. An estimate of the likelihood of …