A macrocyclic β-sheet peptide containing two nonapeptide segments based on Aβ15–23
(QKLVFFAED) forms fibril-like assemblies of oligomers in the solid state. The X-ray …

Amyloid oligomers play a central role in Alzheimer's and other amyloid diseases, and yet the
structures of these heterogeneous and unstable species are not well understood. To better …

This contribution reports solution-phase structural studies of oligomers of a family of
peptides derived from the β-amyloid peptide (Aβ). We had previously reported the X-ray …

In this paper, we investigate the coassembly of peptides derived from the central and C-
terminal regions of the β-amyloid peptide (Aβ). In the preceding paper, J. Am. Chem. Soc …

Protein amyloid oligomers have been strongly linked to amyloid diseases and can be
intermediates to amyloid fibers. β-Sheets have been identified in amyloid oligomers …

Increasing evidence suggests that soluble aggregates of amyloid-β (Aβ) initiate the
neurotoxicity that eventually leads to dementia in Alzheimer's disease. Knowledge on …

The primary component of the amyloid plaques in Alzheimer's disease (AD) is a highly
ordered fibril composed of the 39− 43 amino acid peptide, β-amyloid (Aβ). The presence of …

Oligomeric and protofibrillar aggregates formed by the amyloid‐β peptide (Aβ) are believed
to be involved in the pathology of Alzheimer's disease. Central to Alzheimer pathology is …

In Alzheimer's disease, aggregation of the β-amyloid peptide (Aβ) results in the formation of
oligomers and fibrils that are associated with neurodegeneration. Aggregation of Aβ occurs …

The aggregation of proteins and peptides in the form of stable and highly ordered amyloid
fibrils is most commonly associated with pathological conditions such as Alzheimer's …