A timely, efficient, and coordinated activation of both CD4 and CD8 T cell subsets following
HCV infection is believed to be essential for HCV control. However, to what extent a failure …

The mechanisms mediating protective immunity to hepatitis C virus (HCV) infection are
incompletely understood because early infection in humans is rarely identified, particularly …

Background Hepatitis C virus (HCV) persistence is associated with impaired CD8 functions.
Whether functional restoration of CD8 T cells chronically exposed to antigen can be …

Vigorous proliferative CD4+ T cell responses are the hallmark of spontaneous clearance of
acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in …

Background & Aims: Acute hepatitis C virus (HCV) infection becomes chronic in the majority
of patients. Although HCV-specific CD4 T-cell response is associated with HCV clearance …

Background CD4+ T cell help is critical in maintaining antiviral immune responses and such
help has been shown to be sustained in acute resolving hepatitis C. In contrast, in evolving …

Background & Aims: Cellular immune responses are thought to play a key role in the
resolution of primary HCV infection. Although it has been consistently shown that CD4+ T …

CD4+ T cell failure is a hallmark of chronic hepatitis C virus (HCV) infection. However, the
mechanisms underlying the impairment and loss of virus-specific CD4+ T cells in persisting …

In the setting of acute hepatitis C virus (HCV) infection, robust HCV-specific CD8+ cytotoxic T
lymphocyte (CTL) responses are associated with initial control of viremia. Despite these …

Over recent years, it has become increasingly accepted that virus-specific CD4+ and CD8+
T cell responses play a major role in outcome and pathogenesis of hepatitis C virus (HCV) …