Background: Rupture of the anterior cruciate ligament (ACL) is a well-known risk factor for
the development of posttraumatic osteoarthritis (PTOA), but patients with the “same injury” …

Small animal models are essential for studying anterior cruciate ligament (ACL) injury, one
of the leading risk factors for post‐traumatic osteoarthritis (PTOA). Non‐surgical models of …

Joint injury is the predominant risk factor for post‐traumatic osteoarthritis development
(PTOA). Several non‐invasive mouse models mimicking human PTOA investigate molecular …

Background: The functional disability and high costs of treating anterior cruciate ligament
(ACL) injuries have generated a great deal of interest in understanding the mechanism of …

Objective Joint trauma can lead to a spectrum of acute lesions, including cartilage
degradation, ligament or meniscus tears, and synovitis, all potentially associated with …

Background Anterior cruciate ligament (ACL) injury incurred from high-impact activities
leads to an increased risk of osteoarthritis. Hypothesis Impact forces that cause ACL failure …

The anterior cruciate ligament (ACL) a relatively common injury in young, physically active
individuals. ACL injuries are seen at high incidence in adolescents playing sports that …

Anterior cruciate ligament (ACL) tears are a common knee injury with a known but poorly
understood association with secondary joint injuries and post‐traumatic osteoarthritis (OA) …

Purpose: While knee osteoarthritis (KOA) is typically a slowly progressive disorder, it has
recently been appreciated that 5-17% of knees rapidly progress (eg from normal to end …

Joint instability and cartilage trauma have been previously studied and identified as key
mediators in the development of posttraumatic osteoarthritis (PTOA). The purpose of this …