Introduction Neonatal lung injury as a consequence of hyperoxia (HO) therapy and ventilator
care contribute to the development of bronchopulmonary dysplasia (BPD). Increased …

Abstract Background Sphingosine-1-Phosphate (S1P) is a bioactive lipid and an
intracellular as well as an extracellular signaling molecule. S1P ligand specifically binds to …

Hyperoxia (HO)-induced lung injury contributes to bronchopulmonary dysplasia (BPD) in
preterm newborns. Intractable wheezing seen in BPD survivors is associated with airway …

Bronchopulmonary dysplasia of the premature newborn is characterized by lung injury,
resulting in alveolar simplification and reduced pulmonary function. Exposure of neonatal …

Hyperoxia-induced lung injury adversely affects ICU patients and neonates on ventilator
assisted breathing. The underlying culprit appears to be reactive oxygen species (ROS) …

Introduction We have earlier shown that hyperoxia (HO)-induced sphingosine kinase 1
(SPHK1)/sphingosine-1-phosphate (S1P) signaling contribute to bronchopulmonary …

Rationale: Disordered extracellular matrix production is a feature of bronchopulmonary
dysplasia (BPD). The basis of this phenomenon is not understood. Objectives: To assess …

Premature infants are born with developing lungs burdened by surfactant deficiency and a
dearth of antioxidant defense systems. Survival rate of such infants has significantly …

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease,
wherein transforming growth factor β (TGF-β) and sphingosine-1-phosphate (S1P) …

The pathological hallmarks of bronchopulmonary dysplasia (BPD), a chronic lung disease of
premature infants, include inflammation, arrested alveolarization, and dysregulated …