Mycobacterial dormancy systems and host responses in tuberculosis

V Peddireddy, SN Doddam, N Ahmed - Frontiers in immunology, 2017 - frontiersin.org
Tuberculosis (TB) caused by the intracellular pathogen, Mycobacterium tuberculosis (Mtb),
claims more than 1.5 million lives worldwide annually. Despite promulgation of multipronged …

Mycobacterium tuberculosis: success through dormancy

M Gengenbacher, SHE Kaufmann - FEMS microbiology reviews, 2012 - academic.oup.com
Tuberculosis (TB) remains a major health threat, killing nearly 2 million individuals around
this globe, annually. The only vaccine, developed almost a century ago, provides limited …

Innate Immunity Holding the Flanks until Reinforced by Adaptive Immunity against Mycobacterium tuberculosis Infection

N Khan, A Vidyarthi, S Javed, JN Agrewala - Frontiers in microbiology, 2016 - frontiersin.org
T cells play a cardinal role in imparting protection against Mycobacterium tuberculosis (Mtb).
However, ample time is required before T-cells are able to evoke efficient effector responses …

Mycobacterium tuberculosis: Manipulator of Protective Immunity

VC Korb, AA Chuturgoon, D Moodley - International journal of molecular …, 2016 - mdpi.com
Mycobacterium tuberculosis (MTB) is one of the most successful pathogens in human history
and remains a global health challenge. MTB has evolved a plethora of strategies to evade …

Host defense mechanisms against Mycobacterium tuberculosis

Q Chai, Z Lu, CH Liu - Cellular and Molecular Life Sciences, 2020 - Springer
Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains the
leading cause of death worldwide from a single infectious pathogen. Mtb is a paradigmatic …

Not to wake a sleeping giant: new insights into host-pathogen interactions identify new targets for vaccination against latent Mycobacterium tuberculosis infection

MY Lin, THM Ottenhoff - 2008 - degruyter.com
Mycobacterium tuberculosis is one of the worlds' most successful and sophisticated
pathogens. It is estimated that over 2 billion people today harbour latent M. tuberculosis …

New insights into the evasion of host innate immunity by Mycobacterium tuberculosis

Q Chai, L Wang, CH Liu, B Ge - Cellular & molecular immunology, 2020 - nature.com
Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that
causes tuberculosis (TB), which remains the leading infectious cause of human death. The …

From infection niche to therapeutic target: the intracellular lifestyle of Mycobacterium tuberculosis

LI Rankine-Wilson, T Shapira, C Sao Emani… - …, 2021 - microbiologyresearch.org
Mycobacterium tuberculosis (Mtb) is an obligate human pathogen killing millions of people
annually. Treatment for tuberculosis is lengthy and complicated, involving multiple drugs …

Mycobacterium tuberculosis: An Adaptable Pathogen Associated With Multiple Human Diseases

Q Chai, Y Zhang, CH Liu - Frontiers in cellular and infection …, 2018 - frontiersin.org
Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB), is an extremely
successful pathogen that adapts to survive within the host. During the latency phase of …

Pathogenicity and virulence of Mycobacterium tuberculosis

KC Rahlwes, BRS Dias, PC Campos… - Virulence, 2023 - Taylor & Francis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …