Diabetes mellitus has afflicted humankind for time immemorial, with its earliest medical
documentation recorded over 3,000 years ago. However, it is only in the past century that …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) in
the developed world. It can develop in the course of both type 1 and type 2 diabetes and as …

Diabetic nephropathy is an important problem in insulin-dependent diabetic patients.
Directly or indirectly it is a major cause of death amongst them and accounts for a great …

Accumulating evidence supports intrinsic genetic susceptibility as an important variable in
the progression of diabetic nephropathy in people. Mice provide an experimental platform of …

Until the early nineteenth century, diabetes mellitus was regarded as a disease of the
kidney, in which there was an increase in the volume of urine and a wasting of the flesh …

Excessive urine output is one of the oldest diseases to be recognized that was dubbed
diabetes in the first century BC Its clinical features and fatal outcome were described by the …

Fifty years ago an observation was published which would alter views on the significance of
the renal lesion in diabetes and which laid the foundations for our understanding of diabetic …

Today the clinical picture of diabetes mellitus is often determined by its late complications.
Diabetic nephropathy appears in about 40% of all diabetic patients with type 1 (insulin …

Diabetes and its devastating complications reduce life expectancy and adversely affect
quality of life amongst those affected, thus, posing immense challenges to many societal …

Diabetic nephropathy is now the most common cause of end-stage renal disease. Heavy
proteinuria and progressive loss of glomerular filtration are late manifestations of the …