γ-H2AX is a sensitive marker of DNA damage induced by metabolically activated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
Y Ibuki, M Shikata, T Toyooka - Toxicology in Vitro, 2015 - Elsevier
(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a nicotine-derived nitrosamine, is a
potent pulmonary carcinogen present in tobacco smoke. DNA adducts induced by …
potent pulmonary carcinogen present in tobacco smoke. DNA adducts induced by …
Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) diastereomers and metabolism by A/J mouse lung microsomes and …
JR Jalas, SS Hecht - Chemical research in toxicology, 2003 - ACS Publications
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
lung carcinogen in mice and rats and is a putative human lung carcinogen. NNK undergoes …
lung carcinogen in mice and rats and is a putative human lung carcinogen. NNK undergoes …
A/J mouse lung tumorigenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by arylalkyl isothiocyanates
SS Hecht, MA Morse, KI Eklind… - Experimental lung …, 1991 - Taylor & Francis
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is an important carcinogen found in
tobacco and tobacco smoke. It is a potent lung tumorigen in rodents and appears to be …
tobacco and tobacco smoke. It is a potent lung tumorigen in rodents and appears to be …
Low Fidelity Bypass of O2-(3-Pyridyl)-4-oxobutylthymine, the Most Persistent Bulky Adduct Produced by the Tobacco Specific Nitrosamine 4-(Methylnitrosamino)-1-(3 …
ASP Gowda, G Krishnegowda, Z Suo… - Chemical research in …, 2012 - ACS Publications
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the most important human
carcinogens. It is metabolized to produce a variety of methyl and 4-(3-pyridyl)-4-oxo-butyl …
carcinogens. It is metabolized to produce a variety of methyl and 4-(3-pyridyl)-4-oxo-butyl …
Identification of O2-Substituted Pyrimidine Adducts Formed in Reactions of 4-(Acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(Acetoxymethylnitros …
SS Hecht, PW Villalta, SJ Sturla, G Cheng… - Chemical research in …, 2004 - ACS Publications
Metabolic hydroxylation of the methyl group of the tobacco specific carcinogen 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4 …
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4 …
Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes.
TJ Smith, AM Liao, Y Liu, AB Jones… - …, 1997 - academic.oup.com
(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent tobacco-specific carcinogen
in animals. Our previous studies indicated that there are differences between rodents and …
in animals. Our previous studies indicated that there are differences between rodents and …
Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1 …
(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is metabolized to enantiomers of 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), found in the urine of virtually all people …
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), found in the urine of virtually all people …
Analysis for N2-(pyridyloxobutyl) deoxyguanosine adducts in DNA of tissues exposed to tritium labeled 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N' …
TE Spratt, N Trushin, D Lin… - Chemical research in …, 1989 - ACS Publications
The tobacco-specific carcinogens 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone (NNK) and-
nitrosonornicotine (NNN) are metabolically activated to DNA binding intermediates, partially …
nitrosonornicotine (NNN) are metabolically activated to DNA binding intermediates, partially …
Mass spectrometric quantitation of apurinic/apyrimidinic sites in tissue DNA of rats exposed to tobacco-specific nitrosamines and in lung and leukocyte DNA of …
Metabolic activation of the carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-
1-(3-pyridyl)-1-butanone (NNK) and N′-nitrosonornicotine (NNN) results in formation of …
1-(3-pyridyl)-1-butanone (NNK) and N′-nitrosonornicotine (NNN) results in formation of …
Mass spectrometric analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone-releasing DNA adducts in human lung
D Hölzle, D Schlöbe, AR Tricker, E Richter - Toxicology, 2007 - Elsevier
An improved analytical method was developed for the analysis of 4-hydroxy-1-(3-pyridyl)-1-
butanone (HPB)-releasing DNA adducts in lung samples of patients undergoing surgery for …
butanone (HPB)-releasing DNA adducts in lung samples of patients undergoing surgery for …