The transcription factor hypoxia inducible factor α‐subunit (HIFα) is pivotal in the cellular
response to the stress of hypoxia. Post‐translational modification of HIFα by hydroxylase …

Many molecular and physiological responses to hypoxia in mammals are controlled by the
transcription factors Hypoxia-Inducible Factor-1α (HIF-1α) and HIF-2α. Their ability to …

Hypoxia-inducible factor-1 (HIF-1), the master regulator of transcriptional responses to
reduced oxygen tension (hypoxia) in mammalian cells, consists of one HIF-1α and one HIF …

Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator of various genes related to
cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF‐1 …

Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays
essential roles in mammalian development, physiology and disease pathogenesis. The HIF …

Oxygen homeostasis is a cornerstone of both the physiology and intermediary metabolism
systems. Despite the explosion of knowledge brought about by recombinant DNA …

Hypoxia-inducible factor (HIF) is a sequence-specific DNA-binding protein that can promote
or repress the transcription of a broad range of genes that are involved in maintaining …

Abstract Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of
transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is …

Humans, like other complex aerobic organisms, possess highly evolved systems for the
delivery of dioxygen to all the cells of the body. These systems are regulated since …

Hypoxia-inducible factor (HIF) is an α, β-heterodimeric transcription factor that mediates
cellular responses to low oxygen concentration via the transcriptional activation of specific …