Hypoxia-induced pulmonary arterial constriction can burden circulation in individuals
ascending to high altitudes. In individuals with healthy hearts, the right ventricle effectively …

Objective High altitude-related hypoxia induces pulmonary vasoconstriction. In Fontan
patients without a contractile subpulmonary ventricle, an increase in pulmonary artery …

Background Traveling to high altitude has become more popular. High‐altitude exposure
causes hypobaric hypoxia. Exposure to acute high altitude, during air travel or mountain …

Objectives: Activities with hypoxia exposure such as mountain hiking or especially traveling
by planes become more usual in our everyday life. In healthy individuals, hypoxia leads to …

Purpose For Fontan-palliated patients, altitude exposure is still a part of discussion since the
extent of hypoxic pulmonary vasoconstriction potentially resulting in decreasing cardiac …

BackgroundData assessing the effect of altitude on Fontan haemodynamics are limited to
experimental models and case reports. Both suggest a detrimental impact. This study …

Introduction At cruising altitude, the cabin pressure of passenger aircraft needs to be
adjusted and, therefore, the oxygen content is equivalent to ambient air at 2,500 masl …

Background Hypobaric hypoxia (HH) during flight might be more detrimental to pulmonary
circulation in Fontan patients compared healthy individuals. This study was designed to …

Objective Physical activity at high altitude is expected to pose risks for patients with Fontan
circulation and to impair systemic ventricular function. This study aims to determine the effect …

Exercise performance declines as patients who have undergone Fontan operation enter
adolescence. However, the effect of altitude on functional capacity after Fontan remains …