Synthetic gene circuits perturb the physiology of their cellular host. The extra load on
endogenous processes shifts the equilibrium of resource allocation in the host, leading to …

A century ago, Gertrude Stein told us that a rose is a rose is a rose, but today, modern
genomics is telling us that a pathogen is not a pathogen. Advances in pathogenomics have …

The vast majority of experimental data have been accumulated on the transcription
regulation of individual genes within a single model prokaryote, Escherichia coli, which form …

Abstract The Standard European Vector Architecture 2.0 database (SEVA-DB 2.0,
http://seva. cnb. csic. es) is an improved and expanded version of the platform released in …

Bacteria construct elaborate nanostructures, obtain nutrients and energy from diverse
sources, synthesize complex molecules, and implement signal processing to react to their …

For many regulators of bacterial biodegradation pathways, small molecule/effector binding is
the signal for triggering transcriptional activation. Thus, regulation results from a cross-talk …

Throughout the 3000 million years that bacteria have been on planet Earth, they have
evolved amazing mechanisms for rapid adaptation to every imaginable type of …

Highlights•Directed evolution allows complex trait engineering at a systems-scale.•Synthetic
biology accelerates directed evolution with diversity generation tools.•Synthetic biology can …

Microorganisms in most ecological niches are constantly exposed to variations of many
environmental factors, including temperature; oxygen, nutrient, and water availability; …

Bacteria use a variety of mechanisms to direct RNA polymerase to specific promoters in
order to activate transcription in response to growth signals or environmental cues …