Bacteria use a variety of mechanisms to direct RNA polymerase to specific promoters in
order to activate transcription in response to growth signals or environmental cues …

Over millions of years the structure and complexity of the transcriptional regulatory network
(TRN) in bacteria has changed, reorganized and enabled them to adapt to almost every …

The experimental design of a minimal synthetic genome revealed the presence of a large
number of genes without ascribed function, in part because the abstract laws of life must be …

Microbial-derived natural products (NPs) and their derivative products are of great
importance and used widely in many fields, especially in pharmaceutical industries …

Global explorations of regulatory network dynamics, organization and evolution have
become tractable thanks to high-throughput sequencing and molecular measurement of …

Natural and engineered genetic systems require the coordinated expression of proteins. In
bacteria, translational coupling provides a genetically encoded mechanism to control …

The Escherichia coli transcription network has an essentially feedforward structure, with
abundant feedback at the level of self-regulations. Here, we investigate how these …

The importance of regulatory control in metabolic processes is widely acknowledged, and
several enquiries (both local and global) are being made in understanding regulation at …

SUMMARY A wide variety of mechanisms that control gene expression in bacteria are
based on conditional transcription termination. Generally, in these mechanisms, a …

Taking advantage of available functional data associated with 115 transcription and 7 sigma
factors, we have performed a structural analysis of the regulatory network of Escherichia coli …