Transcription of DNA is a fundamental process in all cellular organisms. The enzyme
responsible for transcription, RNA polymerase, is conserved in general architecture and …

Synthetic control of gene expression is critical for metabolic engineering efforts. Specifically,
precise control of key pathway enzymes (heterologous or native) can help maximize product …

Bacteria must rapidly respond to both intracellular and environmental changes to survive.
One critical mechanism to rapidly detect and adapt to changes in environmental conditions …

Bacterial regulators of transcriptional elongation are versatile units for building custom
genetic switches, as they control the expression of both coding and noncoding RNAs, act on …

Recent advances in metabolic engineering have led to new methods for the synthesis of
novel molecules, improved production of existing compounds and improved degradation of …

Clustering of functionally related genes in operons allows for coregulated gene expression
in prokaryotes. This is advantageous when equal amounts of gene products are required …

The inability to predict heterologous gene expression levels precisely hinders our ability to
engineer biological systems. Using well-characterized regulatory elements offers a potential …